Search Results

Overview

Uniprot IDP37802
Protein NameTransgelin-2
Gene NameTAGLN2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
153 GDPNWFPKKSKENPR
17 LSREVQQKIEKQYDA
171 DNQLQEGKNVIGLQM
40 WITTQCRKDVGRPQP
79 EGQAPVKKIQASTMA

Function

No function data available.

Protein Sequence

10 MANRGPAYGL 20 SREVQQKIEK 30 QYDADLEQIL 40 IQWITTQCRK 50 DVGRPQPGRE 60 NFQNWLKDGT 70 VLCELINALY 80 PEGQAPVKKI 90 QASTMAFKQM 100 EQISQFLQAA 110 ERYGINTTDI 120 FQTVDLWEGK 130 NMACVQRTLM 140 NLGGLAVARD 150 DGLFSGDPNW 160 FPKKSKENPR 170 NFSDNQLQEG 180 KNVIGLQMGT 190 NRGASQAGMT GYGMPRQIL

Gene Ontology

Classification GO ID Description
Biological Process GO:0007015 actin filament organization
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0031982 vesicle
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Biological Process GO:0030855 epithelial cell differentiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.