Search Results
Overview
| Uniprot ID | P37840 |
|---|---|
| Protein Name | Alpha-synuclein |
| Gene Name | SNCA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 12 | MKGLSKAKEGVVAAA |
| 23 | VAAAEKTKQGVAEAA |
| 32 | GVAEAAGKTKEGVLY |
| 34 | AEAAGKTKEGVLYVG |
| 45 | LYVGSKTKEGVVHGV |
| 60 | ATVAEKTKEQVTNVG |
| 96 | AAATGFVKKDQLGKN |
| 97 | AATGFVKKDQLGKNE |
Function
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590)
Protein Sequence
10
MDVFMKGLSK
20
AKEGVVAAAE
30
KTKQGVAEAA
40
GKTKEGVLYV
50
GSKTKEGVVH
60
GVATVAEKTK
70
EQVTNVGGAV
80
VTGVTAVAQK
90
TVEGAGSIAA
100
ATGFVKKDQL
110
GKNEEGAPQE
120
GILEDMPVDP
130
DNEAYEMPSE
140
EGYQDYEPEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0016234 | inclusion body |
| Cellular Component | GO:0097413 | Lewy body |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005640 | nuclear outer membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Biological Process | GO:1904307 | response to desipramine |
| Biological Process | GO:0070555 | response to interleukin-1 |
| Biological Process | GO:0010040 | response to iron(II) ion |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0032026 | response to magnesium ion |
| Biological Process | GO:0034341 | response to type II interferon |
| Biological Process | GO:0035493 | SNARE complex assembly |
| Biological Process | GO:0097435 | supramolecular fiber organization |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0001963 | synaptic transmission, dopaminergic |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Biological Process | GO:0016082 | synaptic vesicle priming |
| Biological Process | GO:0048489 | synaptic vesicle transport |
| Cellular Component | GO:0005840 | ribosome |
| Cellular Component | GO:0099512 | supramolecular fiber |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0043014 | alpha-tubulin binding |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:1903136 | cuprous ion binding |
| Molecular Function | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0070840 | dynein complex binding |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0004857 | enzyme inhibitor activity |
| Molecular Function | GO:0008198 | ferrous iron binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019894 | kinesin binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Molecular Function | GO:0043274 | phospholipase binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0004860 | protein kinase inhibitor activity |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0048156 | tau protein binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0141108 | transporter regulator activity |
| Molecular Function | GO:0015631 | tubulin binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0048148 | behavioral response to cocaine |
| Biological Process | GO:0071280 | cellular response to copper ion |
| Biological Process | GO:0071872 | cellular response to epinephrine stimulus |
| Biological Process | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0042416 | dopamine biosynthetic process |
| Biological Process | GO:0051583 | dopamine uptake involved in synaptic transmission |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0001774 | microglial cell activation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:1904715 | negative regulation of chaperone-mediated autophagy |
| Biological Process | GO:0045963 | negative regulation of dopamine metabolic process |
| Biological Process | GO:0051585 | negative regulation of dopamine uptake involved in synaptic transmission |
| Biological Process | GO:0045920 | negative regulation of exocytosis |
| Biological Process | GO:0031115 | negative regulation of microtubule polymerization |
| Biological Process | GO:1902957 | negative regulation of mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0051622 | negative regulation of norepinephrine uptake |
| Biological Process | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway |
| Biological Process | GO:0051612 | negative regulation of serotonin uptake |
| Biological Process | GO:0070495 | negative regulation of thrombin-activated receptor signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0045807 | positive regulation of endocytosis |
| Biological Process | GO:0045921 | positive regulation of exocytosis |
| Biological Process | GO:1903285 | positive regulation of hydrogen peroxide catabolic process |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0060732 | positive regulation of inositol phosphate biosynthetic process |
| Biological Process | GO:1904377 | positive regulation of protein localization to cell periphery |
| Biological Process | GO:0001921 | positive regulation of receptor recycling |
| Biological Process | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| Biological Process | GO:0035543 | positive regulation of SNARE complex assembly |
| Biological Process | GO:0031648 | protein destabilization |
| Biological Process | GO:0051262 | protein tetramerization |
| Biological Process | GO:0031623 | receptor internalization |
| Biological Process | GO:0014059 | regulation of dopamine secretion |
| Biological Process | GO:0070507 | regulation of microtubule cytoskeleton organization |
| Biological Process | GO:0051621 | regulation of norepinephrine uptake |
| Biological Process | GO:1905606 | regulation of presynapse assembly |
| Biological Process | GO:1903426 | regulation of reactive oxygen species biosynthetic process |
| Biological Process | GO:1903421 | regulation of synaptic vesicle recycling |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.