Search Results

Overview

Uniprot IDP38117
Protein NameElectron transfer flavoprotein subunit beta
Gene NameETFB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
11 LRVLVAVKRVIDYAV
116 AKLAEKEKVDLVLLG
176 GLETLRLKLPAVVTA
19 RVIDYAVKIRVKPDR
205 IMKAKKKKIEVIKPG
210 KKKIEVIKPGDLGVD
238 PQRTAGVKVETTEDL
248 TTEDLVAKLKEIGRI
59 LKEKKLVKEVIAVSC

Function

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:15159392, PubMed:15975918, PubMed:25416781). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:15159392, PubMed:15975918, PubMed:8962055)

Protein Sequence

10 MAELRVLVAV 20 KRVIDYAVKI 30 RVKPDRTGVV 40 TDGVKHSMNP 50 FCEIAVEEAV 60 RLKEKKLVKE 70 VIAVSCGPAQ 80 CQETIRTALA 90 MGADRGIHVE 100 VPPAEAERLG 110 PLQVARVLAK 120 LAEKEKVDLV 130 LLGKQAIDDD 140 CNQTGQMTAG 150 FLDWPQGTFA 160 SQVTLEGDKL 170 KVEREIDGGL 180 ETLRLKLPAV 190 VTADLRLNEP 200 RYATLPNIMK 210 AKKKKIEVIK 220 PGDLGVDLTS 230 KLSVISVEDP 240 PQRTAGVKVE 250 TTEDLVAKLK EIGRI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045251 electron transfer flavoprotein complex
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0009055 electron transfer activity
Biological Process GO:0009063 amino acid catabolic process
Biological Process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
Biological Process GO:0022904 respiratory electron transport chain

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.