Search Results
Overview
| Uniprot ID | P38398 |
|---|---|
| Protein Name | Breast cancer type 1 susceptibility protein |
| Gene Name | BRCA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 501 | QERPLTNKLKRKRRP |
| 711 | NAPGSFTKCSNTSEL |
| 947 | DNAKCSIKGGSRFCL |
Function
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719)
Protein Sequence
10
MDLSALRVEE
20
VQNVINAMQK
30
ILECPICLEL
40
IKEPVSTKCD
50
HIFCKFCMLK
60
LLNQKKGPSQ
70
CPLCKNDITK
80
RSLQESTRFS
90
QLVEELLKII
100
CAFQLDTGLE
110
YANSYNFAKK
120
ENNSPEHLKD
130
EVSIIQSMGY
140
RNRAKRLLQS
150
EPENPSLQET
160
SLSVQLSNLG
170
TVRTLRTKQR
180
IQPQKTSVYI
190
ELGSDSSEDT
200
VNKATYCSVG
210
DQELLQITPQ
220
GTRDEISLDS
230
AKKAACEFSE
240
TDVTNTEHHQ
250
PSNNDLNTTE
260
KRAAERHPEK
270
YQGSSVSNLH
280
VEPCGTNTHA
290
SSLQHENSSL
300
LLTKDRMNVE
310
KAEFCNKSKQ
320
PGLARSQHNR
330
WAGSKETCND
340
RRTPSTEKKV
350
DLNADPLCER
360
KEWNKQKLPC
370
SENPRDTEDV
380
PWITLNSSIQ
390
KVNEWFSRSD
400
ELLGSDDSHD
410
GESESNAKVA
420
DVLDVLNEVD
430
EYSGSSEKID
440
LLASDPHEAL
450
ICKSERVHSK
460
SVESNIEDKI
470
FGKTYRKKAS
480
LPNLSHVTEN
490
LIIGAFVTEP
500
QIIQERPLTN
510
KLKRKRRPTS
520
GLHPEDFIKK
530
ADLAVQKTPE
540
MINQGTNQTE
550
QNGQVMNITN
560
SGHENKTKGD
570
SIQNEKNPNP
580
IESLEKESAF
590
KTKAEPISSS
600
ISNMELELNI
610
HNSKAPKKNR
620
LRRKSSTRHI
630
HALELVVSRN
640
LSPPNCTELQ
650
IDSCSSSEEI
660
KKKKYNQMPV
670
RHSRNLQLME
680
GKEPATGAKK
690
SNKPNEQTSK
700
RHDSDTFPEL
710
KLTNAPGSFT
720
KCSNTSELKE
730
FVNPSLPREE
740
KEEKLETVKV
750
SNNAEDPKDL
760
MLSGERVLQT
770
ERSVESSSIS
780
LVPGTDYGTQ
790
ESISLLEVST
800
LGKAKTEPNK
810
CVSQCAAFEN
820
PKGLIHGCSK
830
DNRNDTEGFK
840
YPLGHEVNHS
850
RETSIEMEES
860
ELDAQYLQNT
870
FKVSKRQSFA
880
PFSNPGNAEE
890
ECATFSAHSG
900
SLKKQSPKVT
910
FECEQKEENQ
920
GKNESNIKPV
930
QTVNITAGFP
940
VVGQKDKPVD
950
NAKCSIKGGS
960
RFCLSSQFRG
970
NETGLITPNK
980
HGLLQNPYRI
990
PPLFPIKSFV
1000
KTKCKKNLLE
1010
ENFEEHSMSP
1020
EREMGNENIP
1030
STVSTISRNN
1040
IRENVFKEAS
1050
SSNINEVGSS
1060
TNEVGSSINE
1070
IGSSDENIQA
1080
ELGRNRGPKL
1090
NAMLRLGVLQ
1100
PEVYKQSLPG
1110
SNCKHPEIKK
1120
QEYEEVVQTV
1130
NTDFSPYLIS
1140
DNLEQPMGSS
1150
HASQVCSETP
1160
DDLLDDGEIK
1170
EDTSFAENDI
1180
KESSAVFSKS
1190
VQKGELSRSP
1200
SPFTHTHLAQ
1210
GYRRGAKKLE
1220
SSEENLSSED
1230
EELPCFQHLL
1240
FGKVNNIPSQ
1250
STRHSTVATE
1260
CLSKNTEENL
1270
LSLKNSLNDC
1280
SNQVILAKAS
1290
QEHHLSEETK
1300
CSASLFSSQC
1310
SELEDLTANT
1320
NTQDPFLIGS
1330
SKQMRHQSES
1340
QGVGLSDKEL
1350
VSDDEERGTG
1360
LEENNQEEQS
1370
MDSNLGEAAS
1380
GCESETSVSE
1390
DCSGLSSQSD
1400
ILTTQQRDTM
1410
QHNLIKLQQE
1420
MAELEAVLEQ
1430
HGSQPSNSYP
1440
SIISDSSALE
1450
DLRNPEQSTS
1460
EKAVLTSQKS
1470
SEYPISQNPE
1480
GLSADKFEVS
1490
ADSSTSKNKE
1500
PGVERSSPSK
1510
CPSLDDRWYM
1520
HSCSGSLQNR
1530
NYPSQEELIK
1540
VVDVEEQQLE
1550
ESGPHDLTET
1560
SYLPRQDLEG
1570
TPYLESGISL
1580
FSDDPESDPS
1590
EDRAPESARV
1600
GNIPSSTSAL
1610
KVPQLKVAES
1620
AQSPAAAHTT
1630
DTAGYNAMEE
1640
SVSREKPELT
1650
ASTERVNKRM
1660
SMVVSGLTPE
1670
EFMLVYKFAR
1680
KHHITLTNLI
1690
TEETTHVVMK
1700
TDAEFVCERT
1710
LKYFLGIAGG
1720
KWVVSYFWVT
1730
QSIKERKMLN
1740
EHDFEVRGDV
1750
VNGRNHQGPK
1760
RARESQDRKI
1770
FRGLEICCYG
1780
PFTNMPTDQL
1790
EWMVQLCGAS
1800
VVKELSSFTL
1810
GTGVHPIVVV
1820
QPDAWTEDNG
1830
FHAIGQMCEA
1840
PVVTREWVLD
1850
SVALYQCQEL
1860
DTYLIPQIPH
SHY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070531 | BRCA1-A complex |
| Cellular Component | GO:0031436 | BRCA1-BARD1 complex |
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0000931 | gamma-tubulin ring complex |
| Cellular Component | GO:0000800 | lateral element |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0000151 | ubiquitin ligase complex |
| Cellular Component | GO:0001741 | XY body |
| Molecular Function | GO:0003684 | damaged DNA binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0140863 | histone H2AK127 ubiquitin ligase activity |
| Molecular Function | GO:0140864 | histone H2AK129 ubiquitin ligase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0070063 | RNA polymerase binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0015631 | tubulin binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0061649 | ubiquitin-modified histone reader activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071681 | cellular response to indole-3-methanol |
| Biological Process | GO:0071479 | cellular response to ionizing radiation |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0043009 | chordate embryonic development |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006301 | DNA damage tolerance |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0110025 | DNA strand resection involved in replication fork processing |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006302 | double-strand break repair |
| Biological Process | GO:0000724 | double-strand break repair via homologous recombination |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0035825 | homologous recombination |
| Biological Process | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| Biological Process | GO:0007095 | mitotic G2 DNA damage checkpoint signaling |
| Biological Process | GO:0044818 | mitotic G2/M transition checkpoint |
| Biological Process | GO:0045786 | negative regulation of cell cycle |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0046600 | negative regulation of centriole replication |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0045717 | negative regulation of fatty acid biosynthetic process |
| Biological Process | GO:0044027 | negative regulation of gene expression via chromosomal CpG island methylation |
| Biological Process | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway |
| Biological Process | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0045739 | positive regulation of DNA repair |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| Biological Process | GO:0051865 | protein autoubiquitination |
| Biological Process | GO:0085020 | protein K6-linked ubiquitination |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:2000001 | regulation of DNA damage checkpoint |
| Biological Process | GO:0006282 | regulation of DNA repair |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010212 | response to ionizing radiation |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.