Search Results

Overview

Uniprot IDP38432
Protein NameCoilin
Gene NameCOIL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
160 VTDQTVSKKNKRKNK
167 KKNKRKNKATCGTVG
209 SPKVQAVKDWANQRC
308 SLTPSKGKTSGTTSS
405 EENLFSWKGAKGRGM

Function

Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs

Protein Sequence

10 MAASETVRLR 20 LQFDYPPPAT 30 PHCTAFWLLV 40 DLNRCRVVTD 50 LISLIRQRFG 60 FSSGAFLGLY 70 LEGGLLPPAE 80 SARLVRDNDC 90 LRVKLEERGV 100 AENSVVISNG 110 DINLSLRKAK 120 KRAFQLEEGE 130 ETEPDCKYSK 140 KHWKSRENNN 150 NNEKVLDLEP 160 KAVTDQTVSK 170 KNKRKNKATC 180 GTVGDDNEEA 190 KRKSPKKKEK 200 CEYKKKAKNP 210 KSPKVQAVKD 220 WANQRCSSPK 230 GSARNSLVKA 240 KRKGSVSVCS 250 KESPSSSSES 260 ESCDESISDG 270 PSKVTLEARN 280 SSEKLPTELS 290 KEEPSTKNTT 300 ADKLAIKLGF 310 SLTPSKGKTS 320 GTTSSSSDSS 330 AESDDQCLMS 340 SSTPECAAGF 350 LKTVGLFAGR 360 GRPGPGLSSQ 370 TAGAAGWRRS 380 GSNGGGQAPG 390 ASPSVSLPAS 400 LGRGWGREEN 410 LFSWKGAKGR 420 GMRGRGRGRG 430 HPVSCVVNRS 440 TDNQRQQQLN 450 DVVKNSSTII 460 QNPVETPKKD 470 YSLLPLLAAA 480 PQVGEKIAFK 490 LLELTSSYSP 500 DVSDYKEGRI 510 LSHNPETQQV 520 DIEILSSLPA 530 LREPGKFDLV 540 YHNENGAEVV 550 EYAVTQESKI 560 TVFWKELIDP 570 RLIIESPSNT SSTEPA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0016020 membrane
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0030619 U1 snRNA binding
Molecular Function GO:0030620 U2 snRNA binding
Biological Process GO:0000387 spliceosomal snRNP assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.