Search Results
Overview
| Uniprot ID | P38656 |
|---|---|
| Protein Name | Lupus La protein homolog |
| Gene Name | Ssb |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 174 | FVDTPGQKYKDTNLL |
| 303 | RNKKVTWKVLEGHAE |
| 316 | AEKDAMKKITDDQQE |
| 340 | GHAARRFKGSHVFTA |
| 356 | RRFKGRGKGNRPAYA |
| 404 | DREEPASKHKKRENG |
| 76 | VQALSKSKANLMEVS |
Function
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation
Protein Sequence
10
MAENGDNEKM
20
AALEAKICHQ
30
IEYYFGDFNL
40
PRDKFLKEQI
50
KLDEGWVPLE
60
TMIKFNRLNR
70
LTTDFNVIVQ
80
ALSKSKANLM
90
EVSADKTKIR
100
RSPSRPLPEV
110
TDEYKNDVKN
120
RSVYIKGFPT
130
DATLDDIKEW
140
LDDKGQILNI
150
QMRRTLHKTF
160
KGSIFAVFDS
170
IQSAKKFVDT
180
PGQKYKDTNL
190
LILFKEDYFA
200
KKNEERKQSK
210
VEAKLKAKQE
220
HEGRHKPGST
230
ETRALEGKMG
240
CLLKFSGDLD
250
DQTCREDFHF
260
LFSNHGEIKW
270
IDFVRGAKEG
280
IILFKEKAKD
290
ALEKARSANN
300
GNLLLRNKKV
310
TWKVLEGHAE
320
KDAMKKITDD
330
QQESLNKWKS
340
KGGHAARRFK
350
GSHVFTAARR
360
FKGRGKGNRP
370
AYAGAPKGRG
380
QFQGRRTRFD
390
DDDHRRGPVK
400
RGIDGRDREE
410
PASKHKKREN
GARDK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0008266 | poly(U) RNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:1990825 | sequence-specific mRNA binding |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0075522 | IRES-dependent viral translational initiation |
| Biological Process | GO:0071045 | nuclear histone mRNA catabolic process |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:1903608 | protein localization to cytoplasmic stress granule |
| Biological Process | GO:0042780 | tRNA 3'-end processing |
| Biological Process | GO:0001682 | tRNA 5'-leader removal |
| Biological Process | GO:0006409 | tRNA export from nucleus |
| Biological Process | GO:0008033 | tRNA processing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.