Search Results
Overview
| Uniprot ID | P38718 |
|---|---|
| Protein Name | Mitochondrial pyruvate carrier 2 |
| Gene Name | Mpc2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 26 | KVELLLPKKLRPLYN |
| 27 | VELLLPKKLRPLYNH |
Function
Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (By similarity). Plays an essential role in cellular metabolism (By similarity)
Protein Sequence
10
MAAAGARGLR
20
ATYHRLMDKV
30
ELLLPKKLRP
40
LYNHPAGPRT
50
VFFWAPIMKW
60
GLVCAGLADM
70
ARPAEKLSTA
80
QSTVLMATGF
90
IWSRYSLVII
100
PKNWSLFAVN
110
FFVGSAGASQ
120
LFRIWKYNQE
LKSKGIQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0098800 | inner mitochondrial membrane protein complex |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:7770001 | mitochondrial pyruvate carrier complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0050833 | pyruvate transmembrane transporter activity |
| Biological Process | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process | GO:0006086 | pyruvate decarboxylation to acetyl-CoA |
| Biological Process | GO:0006850 | pyruvate import into mitochondria |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.