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Overview

Uniprot IDP38935
Protein NameDNA-binding protein SMUBP-2
Gene NameIGHMBP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
150 VTYRRLKKALIALKK
976 LQRRLDKKLSELSNQ

Function

5' to 3' helicase that unwinds both RNA and DNA duplexes in an ATP-dependent reaction (Probable) (PubMed:19158098, PubMed:30218034). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). Has low processivity (PubMed:30218034)

Protein Sequence

10 MASAAVESFV 20 TKQLDLLELE 30 RDAEVEERRS 40 WQENISLKEL 50 QSRGVCLLKL 60 QVSSQRTGLY 70 GRLLVTFEPR 80 RYGSAAALPS 90 NSFTSGDIVG 100 LYDAANEGSQ 110 LATGILTRVT 120 QKSVTVAFDE 130 SHDFQLSLDR 140 ENSYRLLKLA 150 NDVTYRRLKK 160 ALIALKKYHS 170 GPASSLIEVL 180 FGRSAPSPAS 190 EIHPLTFFNT 200 CLDTSQKEAV 210 LFALSQKELA 220 IIHGPPGTGK 230 TTTVVEIILQ 240 AVKQGLKVLC 250 CAPSNIAVDN 260 LVERLALCKQ 270 RILRLGHPAR 280 LLESIQQHSL 290 DAVLARSDSA 300 QIVADIRKDI 310 DQVFVKNKKT 320 QDKREKSNFR 330 NEIKLLRKEL 340 KEREEAAMLE 350 SLTSANVVLA 360 TNTGASADGP 370 LKLLPESYFD 380 VVVIDECAQA 390 LEASCWIPLL 400 KARKCILAGD 410 HKQLPPTTVS 420 HKAALAGLSL 430 SLMERLAEEY 440 GARVVRTLTV 450 QYRMHQAIMR 460 WASDTMYLGQ 470 LTAHSSVARH 480 LLRDLPGVAA 490 TEETGVPLLL 500 VDTAGCGLFE 510 LEEEDEQSKG 520 NPGEVRLVSL 530 HIQALVDAGV 540 PARDIAVVSP 550 YNLQVDLLRQ 560 SLVHRHPELE 570 IKSVDGFQGR 580 EKEAVILSFV 590 RSNRKGEVGF 600 LAEDRRINVA 610 VTRARRHVAV 620 ICDSRTVNNH 630 AFLKTLVEYF 640 TQHGEVRTAF 650 EYLDDIVPEN 660 YSHENSQGSS 670 HAATKPQGPA 680 TSTRTGSQRQ 690 EGGQEAAAPA 700 RQGRKKPAGK 710 SLASEAPSQP 720 SLNGGSPEGV 730 ESQDGVDHFR 740 AMIVEFMASK 750 KMQLEFPPSL 760 NSHDRLRVHQ 770 IAEEHGLRHD 780 SSGEGKRRFI 790 TVSKRAPRPR 800 AALGPPAGTG 810 GPAPLQPVPP 820 TPAQTEQPPR 830 EQRGPDQPDL 840 RTLHLERLQR 850 VRSAQGQPAS 860 KEQQASGQQK 870 LPEKKKKKAK 880 GHPATDLPTE 890 EDFEALVSAA 900 VKADNTCGFA 910 KCTAGVTTLG 920 QFCQLCSRRY 930 CLSHHLPEIH 940 GCGERARAHA 950 RQRISREGVL 960 YAGSGTKNGS 970 LDPAKRAQLQ 980 RRLDKKLSEL 990 SNQRTSRRKE RGT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0016020 membrane
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0043139 5'-3' DNA helicase activity
Molecular Function GO:0032574 5'-3' RNA helicase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0008094 ATP-dependent activity, acting on DNA
Molecular Function GO:0008186 ATP-dependent activity, acting on RNA
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003678 DNA helicase activity
Molecular Function GO:0036121 double-stranded DNA helicase activity
Molecular Function GO:0140296 general transcription initiation factor binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0043022 ribosome binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003697 single-stranded DNA binding
Molecular Function GO:0003727 single-stranded RNA binding
Molecular Function GO:0000049 tRNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006351 DNA-templated transcription
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030426 growth cone

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.