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Overview

Uniprot IDP38983
Protein NameSmall ribosomal subunit protein uS2
Gene NameRpsa
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
220 EEQAAAEKAVTKEEF
42 EQYIYKRKSDGIYII
52 GIYIINLKRTWEKLL
89 TGQRAVLKFAAATGA

Function

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA

Protein Sequence

10 MSGGLDVLQM 20 KEEDVLKFLA 30 AGTHLGGTNL 40 DFQMEQYIYK 50 RKSDGIYIIN 60 LKRTWEKLLL 70 AARAIVAIEN 80 PADVSVISSR 90 NTGQRAVLKF 100 AAATGATPIA 110 GRFTPGTFTN 120 QIQAAFREPR 130 LLVVTDPRAD 140 HQPLTEASYV 150 NLPTIALCNT 160 DSPLRYVDIA 170 IPCNNKGAHS 180 VGLMWWMLAR 190 EVLRMRGTIS 200 REHPWEVMPD 210 LYFYRDPEEI 220 EKEEQAAAEK 230 AVTKEEFQGE 240 WTAPAPEFTA 250 AQPEVADWSE 260 GVQVPSVPIQ 270 QFPTEDWSAQ 280 PATEDWSAAP 290 TAQATEWVGA TTEWS

Gene Ontology

Classification GO ID Description
Molecular Function GO:0043236 laminin binding
Molecular Function GO:0005055 laminin receptor activity
Molecular Function GO:0043022 ribosome binding
Molecular Function GO:0003735 structural constituent of ribosome
Biological Process GO:0140374 antiviral innate immune response
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0000028 ribosomal small subunit assembly
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0022626 cytosolic ribosome
Cellular Component GO:0022627 cytosolic small ribosomal subunit
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0015935 small ribosomal subunit
Cellular Component GO:0045202 synapse
Molecular Function GO:0003677 DNA binding

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.