Search Results
Overview
| Uniprot ID | P39069 |
|---|---|
| Protein Name | Adenylate kinase isoenzyme 1 |
| Gene Name | Ak1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | DGYPREVKQGEEFER |
| 147 | DDNEETIKKRLETYY |
| 166 | PVISFYDKRGIVRKV |
| 21 | VGGPGSGKGTQCEKI |
| 27 | GKGTQCEKIVQKYGY |
| 55 | SSGSSRGKMLSSIME |
| 9 | EDKLKKAKIIFVVGG |
Function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001520 | outer dense fiber |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030017 | sarcomere |
| Cellular Component | GO:0036126 | sperm flagellum |
| Molecular Function | GO:0004017 | AMP kinase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0047506 | dAMP kinase activity |
| Molecular Function | GO:0004550 | nucleoside diphosphate kinase activity |
| Biological Process | GO:0046083 | adenine metabolic process |
| Biological Process | GO:0006172 | ADP biosynthetic process |
| Biological Process | GO:0046033 | AMP metabolic process |
| Biological Process | GO:0046034 | ATP metabolic process |
| Biological Process | GO:0021549 | cerebellum development |
| Biological Process | GO:0046103 | inosine biosynthetic process |
| Biological Process | GO:0007517 | muscle organ development |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0009142 | nucleoside triphosphate biosynthetic process |
| Biological Process | GO:0021772 | olfactory bulb development |
| Biological Process | GO:0010828 | positive regulation of D-glucose transmembrane transport |
| Biological Process | GO:0014042 | positive regulation of neuron maturation |
| Biological Process | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0033574 | response to testosterone |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.