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Overview

Uniprot ID	P39880
Protein Name	Homeobox protein cut-like 1
Gene Name	CUX1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1245	PQPQHQLKKPRVVLA
647	RLFQEVPKRRNGSEG

Function

Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator

Protein Sequence

10 MLCVAGARLK 20 RELDATATVL 30 ANRQDESEQS 40 RKRLIEQSRE 50 FKKNTPEDLR 60 KQVAPLLKSF 70 QGEIDALSKR 80 SKEAEAAFLN 90 VYKRLIDVPD 100 PVPALDLGQQ 110 LQLKVQRLHD 120 IETENQKLRE 130 TLEEYNKEFA 140 EVKNQEVTIK 150 ALKEKIREYE 160 QTLKNQAETI 170 ALEKEQKLQN 180 DFAEKERKLQ 190 ETQMSTTSKL 200 EEAEHKVQSL 210 QTALEKTRTE 220 LFDLKTKYDE 230 ETTAKADEIE 240 MIMTDLERAN 250 QRAEVAQREA 260 ETLREQLSSA 270 NHSLQLASQI 280 QKAPDVEQAI 290 EVLTRSSLEV 300 ELAAKEREIA 310 QLVEDVQRLQ 320 ASLTKLRENS 330 ASQISQLEQQ 340 LSAKNSTLKQ 350 LEEKLKGQAD 360 YEEVKKELNI 370 LKSMEFAPSE 380 GAGTQDAAKP 390 LEVLLLEKNR 400 SLQSENAALR 410 ISNSDLSGSA 420 RRKGKDQPES 430 RRPGSLPAPP 440 PSQLPRNPGE 450 QASNTNGTHQ 460 FSPAGLSQDF 470 FSSSLASPSL 480 PLASTGKFAL 490 NSLLQRQLMQ 500 SFYSKAMQEA 510 GSTSMIFSTG 520 PYSTNSISSQ 530 SPLQQSPDVN 540 GMAPSPSQSE 550 SAGSVSEGEE 560 MDTAEIARQV 570 KEQLIKHNIG 580 QRIFGHYVLG 590 LSQGSVSEIL 600 ARPKPWNKLT 610 VRGKEPFHKM 620 KQFLSDEQNI 630 LALRSIQGRQ 640 RENPGQSLNR 650 LFQEVPKRRN 660 GSEGNITTRI 670 RASETGSDEA 680 IKSILEQAKR 690 ELQVQKTAEP 700 AQPSSASGSG 710 NSDDAIRSIL 720 QQARREMEAQ 730 QAALDPALKQ 740 APLSQSDITI 750 LTPKLLSTSP 760 MPTVSSYPPL 770 AISLKKPSAA 780 PEAGASALPN 790 PPALKKEAQD 800 APGLDPQGAA 810 DCAQGVLRQV 820 KNEVGRSGAW 830 KDHWWSAVQP 840 ERRNAASSEE 850 AKAEETGGGK 860 EKGSGGSGGG 870 SQPRAERSQL 880 QGPSSSEYWK 890 EWPSAESPYS 900 QSSELSLTGA 910 SRSETPQNSP 920 LPSSPIVPMS 930 KPTKPSVPPL 940 TPEQYEVYMY 950 QEVDTIELTR 960 QVKEKLAKNG 970 ICQRIFGEKV 980 LGLSQGSVSD 990 MLSRPKPWSK 1000 LTQKGREPFI 1010 RMQLWLNGEL 1020 GQGVLPVQGQ 1030 QQGPVLHSVT 1040 SLQDPLQQGC 1050 VSSESTPKTS 1060 ASCSPAPESP 1070 MSSSESVKSL 1080 TELVQQPCPP 1090 IEASKDSKPP 1100 EPSDPPASDS 1110 QPTTPLPLSG 1120 HSALSIQELV 1130 AMSPELDTYG 1140 ITKRVKEVLT 1150 DNNLGQRLFG 1160 ETILGLTQGS 1170 VSDLLARPKP 1180 WHKLSLKGRE 1190 PFVRMQLWLN 1200 DPNNVEKLMD 1210 MKRMEKKAYM 1220 KRRHSSVSDS 1230 QPCEPPSVGT 1240 EYSQGASPQP 1250 QHQLKKPRVV 1260 LAPEEKEALK 1270 RAYQQKPYPS 1280 PKTIEDLATQ 1290 LNLKTSTVIN 1300 WFHNYRSRIR 1310 RELFIEEIQA 1320 GSQGQAGASD 1330 SPSARSGRAA 1340 PSSEGDSCDG 1350 VEATEGPGSA 1360 DTEEPKSQGE 1370 AEREEVPRPA 1380 EQTEPPPSGT 1390 PGPDDARDDD 1400 HEGGPVEGPG 1410 PLPSPASATA 1420 TAAPAAPEDA 1430 ATSAAAAPGE 1440 GPAAPSSAPP 1450 PSNSSSSSAP 1460 RRPSSLQSLF 1470 GLPEAAGARD 1480 SRDNPLRKKK 1490 AANLNSIIHR 1500 LEKAASREEP IEWEF

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function	GO:0043565	sequence-specific DNA binding
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

PMID: N/A