Search Results
Overview
| Uniprot ID | P39900 |
|---|---|
| Protein Name | Macrophage metalloelastase |
| Gene Name | MMP12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | PGGPVWRKHYITYRI |
Function
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3
Protein Sequence
10
MKFLLILLLQ
20
ATASGALPLN
30
SSTSLEKNNV
40
LFGERYLEKF
50
YGLEINKLPV
60
TKMKYSGNLM
70
KEKIQEMQHF
80
LGLKVTGQLD
90
TSTLEMMHAP
100
RCGVPDVHHF
110
REMPGGPVWR
120
KHYITYRINN
130
YTPDMNREDV
140
DYAIRKAFQV
150
WSNVTPLKFS
160
KINTGMADIL
170
VVFARGAHGD
180
FHAFDGKGGI
190
LAHAFGPGSG
200
IGGDAHFDED
210
EFWTTHSGGT
220
NLFLTAVHEI
230
GHSLGLGHSS
240
DPKAVMFPTY
250
KYVDINTFRL
260
SADDIRGIQS
270
LYGDPKENQR
280
LPNPDNSEPA
290
LCDPNLSFDA
300
VTTVGNKIFF
310
FKDRFFWLKV
320
SERPKTSVNL
330
ISSLWPTLPS
340
GIEAAYEIEA
350
RNQVFLFKDD
360
KYWLISNLRP
370
EPNYPKSIHS
380
FGFPNFVKKI
390
DAAVFNPRFY
400
RTYFFVDNQY
410
WRYDERRQMM
420
DPGYPKLITK
430
NFQGIGPKID
440
AVFYSKNKYY
450
YFFQGSNQFE
460
YDFLLQRITK
470
TLKSNSWFGC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005518 | collagen binding |
| Molecular Function | GO:0001046 | core promoter sequence-specific DNA binding |
| Molecular Function | GO:0004175 | endopeptidase activity |
| Molecular Function | GO:0004222 | metalloendopeptidase activity |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0098586 | cellular response to virus |
| Biological Process | GO:0030574 | collagen catabolic process |
| Biological Process | GO:0060309 | elastin catabolic process |
| Biological Process | GO:0022617 | extracellular matrix disassembly |
| Biological Process | GO:0030198 | extracellular matrix organization |
| Biological Process | GO:1904905 | negative regulation of endothelial cell-matrix adhesion |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway |
| Biological Process | GO:0060054 | positive regulation of epithelial cell proliferation involved in wound healing |
| Biological Process | GO:0032727 | positive regulation of interferon-alpha production |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0050691 | regulation of defense response to virus by host |
| Biological Process | GO:1904645 | response to amyloid-beta |
| Biological Process | GO:0035313 | wound healing, spreading of epidermal cells |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.