Overview
| Uniprot ID | P40112 |
|---|
| Protein Name | Proteasome subunit beta type-3 |
|---|
| Gene Name | Psmb3 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 17 |
AVMAMKGKNCVAIAA |
Function
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
MSVMSYNGGA
20
VMAMKGKNCV
30
AIAADRRFGI
40
QAQMVTTDFQ
50
KIFPMGDRLY
60
IGLAGLATDV
70
QTVAQRLKFR
80
LNLYELKEGR
90
QIKPYTLMSM
100
VANLLYEKRF
110
GPYYTEPVIA
120
GLDPKTFKPF
130
ICSLDLIGCP
140
MVTDDFVVSG
150
TCSEQMYGMC
160
ESLWEPNMDP
170
EHLFETISQA
180
MLNAVDRDAV
190
SGMGVIVHII
200
EKDKITTRTL
KARMD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000502 |
proteasome complex |
| Cellular Component |
GO:0005839 |
proteasome core complex |
| Cellular Component |
GO:0019774 |
proteasome core complex, beta-subunit complex |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Biological Process |
GO:0010498 |
proteasomal protein catabolic process |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.