Search Results

Overview

Uniprot IDP40121
Protein NameMacrophage-capping protein
Gene NameCAPG
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
115 SYFPRGLKYQEGGVE
127 GVESAFHKTSTGAPA
137 TGAPAAIKKLYQVKG
145 KLYQVKGKKNIRATE
231 LGPKPALKEGNPEED
243 EEDLTADKANAQAAA

Function

Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA

Protein Sequence

10 MYTAIPQSGS 20 PFPGSVQDPG 30 LHVWRVEKLK 40 PVPVAQENQG 50 VFFSGDSYLV 60 LHNGPEEVSH 70 LHLWIGQQSS 80 RDEQGACAVL 90 AVHLNTLLGE 100 RPVQHREVQG 110 NESDLFMSYF 120 PRGLKYQEGG 130 VESAFHKTST 140 GAPAAIKKLY 150 QVKGKKNIRA 160 TERALNWDSF 170 NTGDCFILDL 180 GQNIFAWCGG 190 KSNILERNKA 200 RDLALAIRDS 210 ERQGKAQVEI 220 VTDGEEPAEM 230 IQVLGPKPAL 240 KEGNPEEDLT 250 ADKANAQAAA 260 LYKVSDATGQ 270 MNLTKVADSS 280 PFALELLISD 290 DCFVLDNGLC 300 GKIYIWKGRK 310 ANEKERQAAL 320 QVAEGFISRM 330 QYAPNTQVEI 340 LPQGHESPIF KQFFKDWK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005814 centriole
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0008290 F-actin capping protein complex
Cellular Component GO:0090543 Flemming body
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0042470 melanosome
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0001726 ruffle
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0051014 actin filament severing
Biological Process GO:0008154 actin polymerization or depolymerization
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0030031 cell projection assembly
Biological Process GO:0007417 central nervous system development
Biological Process GO:0065003 protein-containing complex assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.