Search Results
Overview
| Uniprot ID | P40123 |
|---|---|
| Protein Name | Adenylyl cyclase-associated protein 2 |
| Gene Name | CAP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | NRVLKDYKHSDLRHV |
| 288 | TDDQKTYKNPSLRAQ |
| 304 | GQTQSPTKSHTPSPT |
| 314 | TPSPTSPKSYPSQKH |
Function
Involved in the regulation of actin polymerization
Protein Sequence
10
MANMQGLVER
20
LERAVSRLES
30
LSAESHRPPG
40
NCGEVNGVIA
50
GVAPSVEAFD
60
KLMDSMVAEF
70
LKNSRILAGD
80
VETHAEMVHS
90
AFQAQRAFLL
100
MASQYQQPHE
110
NDVAALLKPI
120
SEKIQEIQTF
130
RERNRGSNMF
140
NHLSAVSESI
150
PALGWIAVSP
160
KPGPYVKEMN
170
DAATFYTNRV
180
LKDYKHSDLR
190
HVDWVKSYLN
200
IWSELQAYIK
210
EHHTTGLTWS
220
KTGPVASTVS
230
AFSVLSSGPG
240
LPPPPPPLPP
250
PGPPPLFENE
260
GKKEESSPSR
270
SALFAQLNQG
280
EAITKGLRHV
290
TDDQKTYKNP
300
SLRAQGGQTQ
310
SPTKSHTPSP
320
TSPKSYPSQK
330
HAPVLELEGK
340
KWRVEYQEDR
350
NDLVISETEL
360
KQVAYIFKCE
370
KSTIQIKGKV
380
NSIIIDNCKK
390
LGLVFDNVVG
400
IVEVINSQDI
410
QIQVMGRVPT
420
ISINKTEGCH
430
IYLSEDALDC
440
EIVSAKSSEM
450
NILIPQDGDY
460
REFPIPEQFK
470
TAWDGSKLIT
EPAEIMA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0008179 | adenylate cyclase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0007190 | activation of adenylate cyclase activity |
| Biological Process | GO:0000902 | cell morphogenesis |
| Biological Process | GO:0007163 | establishment or maintenance of cell polarity |
| Biological Process | GO:0099140 | presynaptic actin cytoskeleton organization |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.