Overview
| Uniprot ID | P40241 |
|---|
| Protein Name | CD9 antigen |
|---|
| Gene Name | Cd9 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 124 |
KELQEFYKDTYQKLR |
| 168 |
ISDICPKKQVLESFQ |
Function
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity)
Protein Sequence
10
MPVKGGSKCI
20
KYLLFGFNFI
30
FWLAGIAVLA
40
IGLWLRFDSQ
50
TKSIFEQETN
60
HSSFYTGVYI
70
LIGAGALMML
80
VGFLGCCGAV
90
QESQCMLGLF
100
FGFLLVIFAI
110
EIAAAVWGYT
120
HKDEVIKELQ
130
EFYKDTYQKL
140
RNKDEPQRET
150
LKAIHMALNC
160
CGIAGGVEQF
170
ISDICPKKQV
180
LESFQVKSCP
190
DAIDEVFHSK
200
FHIIGAVGIG
210
IAVVMIFGMI
220
FSMILCCAIR
RSREMV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0005178 |
integrin binding |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0071404 |
cellular response to low-density lipoprotein particle stimulus |
| Biological Process |
GO:0007342 |
fusion of sperm to egg plasma membrane involved in single fertilization |
| Biological Process |
GO:0008347 |
glial cell migration |
| Biological Process |
GO:0014905 |
myoblast fusion involved in skeletal muscle regeneration |
| Biological Process |
GO:0008285 |
negative regulation of cell population proliferation |
| Biological Process |
GO:0090331 |
negative regulation of platelet aggregation |
| Biological Process |
GO:0014003 |
oligodendrocyte development |
| Biological Process |
GO:0030913 |
paranodal junction assembly |
| Biological Process |
GO:0031623 |
receptor internalization |
| Biological Process |
GO:1905521 |
regulation of macrophage migration |
| Biological Process |
GO:0007338 |
single fertilization |
| Biological Process |
GO:0035036 |
sperm-egg recognition |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.