Search Results

Overview

Uniprot IDP40306
Protein NameProteasome subunit beta type-10
Gene NamePSMB10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 TTRMVASKMELHALS
236 SSPTEPVKRSGRYHF

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides

Protein Sequence

10 MLKPALEPRG 20 GFSFENCQRN 30 ASLERVLPGL 40 KVPHARKTGT 50 TIAGLVFQDG 60 VILGADTRAT 70 NDSVVADKSC 80 EKIHFIAPKI 90 YCCGAGVAAD 100 AEMTTRMVAS 110 KMELHALSTG 120 REPRVATVTR 130 ILRQTLFRYQ 140 GHVGASLIVG 150 GVDLTGPQLY 160 GVHPHGSYSR 170 LPFTALGSGQ 180 DAALAVLEDR 190 FQPNMTLEAA 200 QGLLVEAVTA 210 GILGDLGSGG 220 NVDACVITKT 230 GAKLLRTLSS 240 PTEPVKRSGR 250 YHFVPGTTAV 260 LTQTVKPLTL 270 ELVEETVQAM EVE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Biological Process GO:0045590 negative regulation of regulatory T cell differentiation
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0032729 positive regulation of type II interferon production
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0010499 proteasomal ubiquitin-independent protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0034341 response to type II interferon
Biological Process GO:0045063 T-helper 1 cell differentiation
Biological Process GO:0072539 T-helper 17 cell differentiation
Biological Process GO:0045061 thymic T cell selection
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0005839 proteasome core complex
Cellular Component GO:0019774 proteasome core complex, beta-subunit complex
Cellular Component GO:1990111 spermatoproteasome complex
Molecular Function GO:0004175 endopeptidase activity
Molecular Function GO:0004298 threonine-type endopeptidase activity
Biological Process GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
Biological Process GO:0043374 CD8-positive, alpha-beta T cell differentiation
Biological Process GO:0160165 CD8-positive, alpha-beta T cell homeostasis
Biological Process GO:0006959 humoral immune response
Biological Process GO:0002376 immune system process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.