Search Results

Overview

Uniprot IDP40763
Protein NameSignal transducer and activator of transcription 3
Gene NameSTAT3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
244 DEELADWKRRQQIAC
294 LQQKVSYKGDPIVQH
370 KIKVCIDKDSGDVAA

Function

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:11294841, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18782771, PubMed:28262505, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (PubMed:28065600, PubMed:28262505). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (PubMed:9188471)

Protein Sequence

10 MAQWNQLQQL 20 DTRYLEQLHQ 30 LYSDSFPMEL 40 RQFLAPWIES 50 QDWAYAASKE 60 SHATLVFHNL 70 LGEIDQQYSR 80 FLQESNVLYQ 90 HNLRRIKQFL 100 QSRYLEKPME 110 IARIVARCLW 120 EESRLLQTAA 130 TAAQQGGQAN 140 HPTAAVVTEK 150 QQMLEQHLQD 160 VRKRVQDLEQ 170 KMKVVENLQD 180 DFDFNYKTLK 190 SQGDMQDLNG 200 NNQSVTRQKM 210 QQLEQMLTAL 220 DQMRRSIVSE 230 LAGLLSAMEY 240 VQKTLTDEEL 250 ADWKRRQQIA 260 CIGGPPNICL 270 DRLENWITSL 280 AESQLQTRQQ 290 IKKLEELQQK 300 VSYKGDPIVQ 310 HRPMLEERIV 320 ELFRNLMKSA 330 FVVERQPCMP 340 MHPDRPLVIK 350 TGVQFTTKVR 360 LLVKFPELNY 370 QLKIKVCIDK 380 DSGDVAALRG 390 SRKFNILGTN 400 TKVMNMEESN 410 NGSLSAEFKH 420 LTLREQRCGN 430 GGRANCDASL 440 IVTEELHLIT 450 FETEVYHQGL 460 KIDLETHSLP 470 VVVISNICQM 480 PNAWASILWY 490 NMLTNNPKNV 500 NFFTKPPIGT 510 WDQVAEVLSW 520 QFSSTTKRGL 530 SIEQLTTLAE 540 KLLGPGVNYS 550 GCQITWAKFC 560 KENMAGKGFS 570 FWVWLDNIID 580 LVKKYILALW 590 NEGYIMGFIS 600 KERERAILST 610 KPPGTFLLRF 620 SESSKEGGVT 630 FTWVEKDISG 640 KTQIQSVEPY 650 TKQQLNNMSF 660 AEIIMGYKIM 670 DATNILVSPL 680 VYLYPDIPKE 690 EAFGKYCRPE 700 SQEHPEADPG 710 SAAPYLKTKF 720 ICVTPTTCSN 730 TIDLPMSPRT 740 LDSLMQFGNN 750 GEGAEPSAGG 760 QFESLTFDME 770 LTSECATSPM

Gene Ontology

Classification GO ID Description
Biological Process GO:0007399 nervous system development
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0031730 CCR5 chemokine receptor binding
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0106222 lncRNA binding
Molecular Function GO:0035259 nuclear glucocorticoid receptor binding
Molecular Function GO:0004879 nuclear receptor activity
Molecular Function GO:0070878 primary miRNA binding
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0019903 protein phosphatase binding
Molecular Function GO:0140311 protein sequestering activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0140610 RNA sequestering activity
Molecular Function GO:0035591 signaling adaptor activity
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Biological Process GO:0006953 acute-phase response
Biological Process GO:0048708 astrocyte differentiation
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007259 cell surface receptor signaling pathway via JAK-STAT
Biological Process GO:0097696 cell surface receptor signaling pathway via STAT
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0097398 cellular response to interleukin-17
Biological Process GO:0044320 cellular response to leptin stimulus
Biological Process GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0006952 defense response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0042755 eating behavior
Biological Process GO:0030968 endoplasmic reticulum unfolded protein response
Biological Process GO:0097009 energy homeostasis
Biological Process GO:0001754 eye photoreceptor cell differentiation
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0060396 growth hormone receptor signaling pathway
Biological Process GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
Biological Process GO:0006954 inflammatory response
Biological Process GO:0140105 interleukin-10-mediated signaling pathway
Biological Process GO:0038154 interleukin-11-mediated signaling pathway
Biological Process GO:0035723 interleukin-15-mediated signaling pathway
Biological Process GO:0038110 interleukin-2-mediated signaling pathway
Biological Process GO:0038155 interleukin-23-mediated signaling pathway
Biological Process GO:0070102 interleukin-6-mediated signaling pathway
Biological Process GO:0038113 interleukin-9-mediated signaling pathway
Biological Process GO:0030522 intracellular receptor signaling pathway
Biological Process GO:0033210 leptin-mediated signaling pathway
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:0043124 negative regulation of canonical NF-kappaB signal transduction
Biological Process GO:1900016 negative regulation of cytokine production involved in inflammatory response
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0010730 negative regulation of hydrogen peroxide biosynthetic process
Biological Process GO:0106015 negative regulation of inflammatory response to wounding
Biological Process GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:2000635 negative regulation of primary miRNA processing
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0002317 plasma cell differentiation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:2001171 positive regulation of ATP biosynthetic process
Biological Process GO:0043123 positive regulation of canonical NF-kappaB signal transduction
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:1900017 positive regulation of cytokine production involved in inflammatory response
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045648 positive regulation of erythrocyte differentiation
Biological Process GO:0090091 positive regulation of extracellular matrix disassembly
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0032733 positive regulation of interleukin-10 production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:1902895 positive regulation of miRNA transcription
Biological Process GO:0045747 positive regulation of Notch signaling pathway
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:1905564 positive regulation of vascular endothelial cell proliferation
Biological Process GO:0010575 positive regulation of vascular endothelial growth factor production
Biological Process GO:0099527 postsynapse to nucleus signaling pathway
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0060019 radial glial cell differentiation
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:1900037 regulation of cellular response to hypoxia
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0060259 regulation of feeding behavior
Biological Process GO:0046902 regulation of mitochondrial membrane permeability
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0032355 response to estradiol
Biological Process GO:0045471 response to ethanol
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0002931 response to ischemia
Biological Process GO:0044321 response to leptin
Biological Process GO:0043434 response to peptide hormone
Biological Process GO:0007165 signal transduction
Biological Process GO:0072540 T-helper 17 cell lineage commitment
Biological Process GO:0072538 T-helper 17 type immune response
Biological Process GO:0001659 temperature homeostasis
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.