Search Results
Overview
| Uniprot ID | P40855 |
|---|---|
| Protein Name | Peroxisomal biogenesis factor 19 |
| Gene Name | PEX19 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 60 | RSPGDTAKDALFASQ |
Function
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53
Protein Sequence
10
MAAAEEGCSV
20
GAEADRELEE
30
LLESALDDFD
40
KAKPSPAPPS
50
TTTAPDASGP
60
QKRSPGDTAK
70
DALFASQEKF
80
FQELFDSELA
90
SQATAEFEKA
100
MKELAEEEPH
110
LVEQFQKLSE
120
AAGRVGSDMT
130
SQQEFTSCLK
140
ETLSGLAKNA
150
TDLQNSSMSE
160
EELTKAMEGL
170
GMDEGDGEGN
180
ILPIMQSIMQ
190
NLLSKDVLYP
200
SLKEITEKYP
210
EWLQSHRESL
220
PPEQFEKYQE
230
QHSVMCKICE
240
QFEAETPTDS
250
ETTQKARFEM
260
VLDLMQQLQD
270
LGHPPKELAG
280
EMPPGLNFDL
290
DALNLSGPPG
ASGEQCLIM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031526 | brush border membrane |
| Molecular Function | GO:0033328 | peroxisome membrane targeting sequence binding |
| Molecular Function | GO:0140597 | protein carrier chaperone |
| Biological Process | GO:0072663 | establishment of protein localization to peroxisome |
| Biological Process | GO:1900131 | negative regulation of lipid binding |
| Biological Process | GO:0016559 | peroxisome fission |
| Biological Process | GO:0016557 | peroxisome membrane biogenesis |
| Biological Process | GO:0007031 | peroxisome organization |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0045046 | protein import into peroxisome membrane |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0006625 | protein targeting to peroxisome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Cellular Component | GO:0005777 | peroxisome |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0036105 | peroxisome membrane class-1 targeting sequence binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.