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Overview

Uniprot IDP41091
Protein NameEukaryotic translation initiation factor 2 subunit 3
Gene NameEIF2S3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
183 AIEIMKLKHILILQN
196 QNKIDLVKESQAKEQ
266 IRSFDVNKPGCEVDD
421 GGRVSAVKADLGKIV
59 HGKSTVVKAISGVHT
90 YANAKIYKLDDPSCP

Function

Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity)

Protein Sequence

10 MAGGEAGVTL 20 GQPHLSRQDL 30 TTLDVTKLTP 40 LSHEVISRQA 50 TINIGTIGHV 60 AHGKSTVVKA 70 ISGVHTVRFK 80 NELERNITIK 90 LGYANAKIYK 100 LDDPSCPRPE 110 CYRSCGSSTP 120 DEFPTDIPGT 130 KGNFKLVRHV 140 SFVDCPGHDI 150 LMATMLNGAA 160 VMDAALLLIA 170 GNESCPQPQT 180 SEHLAAIEIM 190 KLKHILILQN 200 KIDLVKESQA 210 KEQYEQILAF 220 VQGTVAEGAP 230 IIPISAQLKY 240 NIEVVCEYIV 250 KKIPVPPRDF 260 TSEPRLIVIR 270 SFDVNKPGCE 280 VDDLKGGVAG 290 GSILKGVLKV 300 GQEIEVRPGI 310 VSKDSEGKLM 320 CKPIFSKIVS 330 LFAEHNDLQY 340 AAPGGLIGVG 350 TKIDPTLCRA 360 DRMVGQVLGA 370 VGALPEIFTE 380 LEISYFLLRR 390 LLGVRTEGDK 400 KAAKVQKLSK 410 NEVLMVNIGS 420 LSTGGRVSAV 430 KADLGKIVLT 440 NPVCTEVGEK 450 IALSRRVEKH 460 WRLIGWGQIR 470 RGVTIKPTVD DD

Gene Ontology

Classification GO ID Description
Biological Process GO:0006446 regulation of translational initiation
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005850 eukaryotic translation initiation factor 2 complex
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:1990856 methionyl-initiator methionine tRNA binding
Molecular Function GO:0008135 translation factor activity, RNA binding
Molecular Function GO:0003743 translation initiation factor activity
Biological Process GO:0002183 cytoplasmic translational initiation
Biological Process GO:0001731 formation of translation preinitiation complex
Biological Process GO:0006413 translational initiation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.