Overview
| Uniprot ID | P41134 |
|---|
| Protein Name | DNA-binding protein inhibitor ID-1 |
|---|
| Gene Name | ID1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
AGPSCALKAGKTASG |
Function
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity)
Protein Sequence
10
MKVASGSTAT
20
AAAGPSCALK
30
AGKTASGAGE
40
VVRCLSEQSV
50
AISRCAGGAG
60
ARLPALLDEQ
70
QVNVLLYDMN
80
GCYSRLKELV
90
PTLPQNRKVS
100
KVEILQHVID
110
YIRDLQLELN
120
SESEVGTPGG
130
RGLPVRAPLS
140
TLNGEISALT
150
AEAACVPADD
RILCR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0046983 |
protein dimerization activity |
| Molecular Function |
GO:0003714 |
transcription corepressor activity |
| Molecular Function |
GO:0140416 |
transcription regulator inhibitor activity |
| Biological Process |
GO:0001525 |
angiogenesis |
| Biological Process |
GO:0043534 |
blood vessel endothelial cell migration |
| Biological Process |
GO:0048514 |
blood vessel morphogenesis |
| Biological Process |
GO:0007623 |
circadian rhythm |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0120163 |
negative regulation of cold-induced thermogenesis |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0030182 |
neuron differentiation |
| Biological Process |
GO:0010628 |
positive regulation of gene expression |
| Biological Process |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.