Search Results
Overview
| Uniprot ID | P41162 |
|---|---|
| Protein Name | ETS translocation variant 3 |
| Gene Name | ETV3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | KGKRFTYKFNFNKLV |
| 224 | GGGIGHQKRKPDIML |
Function
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity
Protein Sequence
10
MKAGCSIVEK
20
PEGGGGYQFP
30
DWAYKTESSP
40
GSRQIQLWHF
50
ILELLQKEEF
60
RHVIAWQQGE
70
YGEFVIKDPD
80
EVARLWGRRK
90
CKPQMNYDKL
100
SRALRYYYNK
110
RILHKTKGKR
120
FTYKFNFNKL
130
VMPNYPFINI
140
RSSGVVPQSA
150
PPVPTASSRF
160
HFPPLDTHSP
170
TNDVQPGRFS
180
ASSLTASGQE
190
SSNGTDRKTE
200
LSELEDGSAA
210
DWRRGVDPVS
220
SRNAIGGGGI
230
GHQKRKPDIM
240
LPLFARPGMY
250
PDPHSPFAVS
260
PIPGRGGVLN
270
VPISPALSLT
280
PTIFSYSPSP
290
GLSPFTSSSC
300
FSFNPEEMKH
310
YLHSQACSVF
320
NYHLSPRTFP
330
RYPGLMVPPL
340
QCQMHPEEST
350
QFSIKLQPPP
360
VGRKNRERVE
370
SSEESAPVTT
380
PTMASIPPRI
390
KVEPASEKDP
400
ESLRQSAREK
410
EEHTQEEGTV
420
PSRTIEEEKG
430
TIFARPAAPP
440
IWPSVPISTP
450
SGEPLEVTED
460
SEDRPGKEPS
470
APEKKEDALM
480
PPKLRLKRRW
490
NDDPEARELS
500
KSGKFLWNGS
510
GPQGLATAAA
DA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0090571 | RNA polymerase II transcription repressor complex |
| Molecular Function | GO:0017151 | DEAD/H-box RNA helicase binding |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.