Search Results
Overview
| Uniprot ID | P41216 |
|---|---|
| Protein Name | Long-chain-fatty-acid--CoA ligase 1 |
| Gene Name | Acsl1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 208 | ADKPEKAKLLLEGVE |
| 241 | DLVERGKKCGVEIIS |
| 428 | IQSSLGGKVRLMITG |
| 533 | RTAEALDKDGWLHTG |
| 562 | DRKKHIFKLAQGEYI |
| 644 | DDLLKLGKEAGLKPF |
| 676 | GLLTPTLKAKRPELR |
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs)
Protein Sequence
10
MEVHELFRYF
20
RMPELIDIRQ
30
YVRTLPTNTL
40
MGFGAFAALT
50
TFWYATRPKA
60
LKPPCDLSMQ
70
SVEIAGTTDG
80
IRRSAVLEDD
90
KLLVYYYDDV
100
RTMYDGFQRG
110
IQVSNNGPCL
120
GSRKPNQPYE
130
WISYKEVAEL
140
AECIGSGLIQ
150
KGFKPCSEQF
160
IGLFSQNRPE
170
WVIVEQGCFS
180
YSMVVVPLYD
190
TLGADAITYI
200
VNKAELSVIF
210
ADKPEKAKLL
220
LEGVENKLTP
230
CLKIIVIMDS
240
YGSDLVERGK
250
KCGVEIISLK
260
ALEDLGRVNR
270
VKPKPPEPED
280
LAIICFTSGT
290
TGNPKGAMIT
300
HQNIINDCSG
310
FIKATESAFI
320
ASTDDVLISF
330
LPLAHMFETV
340
VECVMLCHGA
350
KIGFFQGDIR
360
LLMDDLKVLQ
370
PTIFPVVPRL
380
LNRMFDRIFG
390
QANTSLKRWL
400
LDFASKRKEA
410
ELRSGIVRNN
420
SLWDKLIFHK
430
IQSSLGGKVR
440
LMITGAAPVS
450
ATVLTFLRTA
460
LGCQFYEGYG
470
QTECTAGCCL
480
SLPGDWTAGH
490
VGAPMPCNYV
500
KLVDVEEMNY
510
LASKGEGEVC
520
VKGANVFKGY
530
LKDPARTAEA
540
LDKDGWLHTG
550
DIGKWLPNGT
560
LKIIDRKKHI
570
FKLAQGEYIA
580
PEKIENIYLR
590
SEAVAQVFVH
600
GESLQAFLIA
610
VVVPDVESLP
620
SWAQKRGLQG
630
SFEELCRNKD
640
INKAILDDLL
650
KLGKEAGLKP
660
FEQVKGIAVH
670
PELFSIDNGL
680
LTPTLKAKRP
690
ELRNYFRSQI
DELYATIKI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Molecular Function | GO:0047676 | arachidonate-CoA ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004467 | long-chain fatty acid-CoA ligase activity |
| Molecular Function | GO:0090434 | oleoyl-CoA ligase activity |
| Molecular Function | GO:0090433 | palmitoyl-CoA ligase activity |
| Molecular Function | GO:0050197 | phytanate-CoA ligase activity |
| Molecular Function | GO:0070251 | pristanate-CoA ligase activity |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Biological Process | GO:0033211 | adiponectin-activated signaling pathway |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0015908 | fatty acid transport |
| Biological Process | GO:0008610 | lipid biosynthetic process |
| Biological Process | GO:0044539 | long-chain fatty acid import into cell |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:0010747 | positive regulation of long-chain fatty acid import across plasma membrane |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0034201 | response to oleic acid |
| Biological Process | GO:0019432 | triglyceride biosynthetic process |
| Biological Process | GO:0000038 | very long-chain fatty acid metabolic process |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.