Search Results
Overview
| Uniprot ID | P41218 |
|---|---|
| Protein Name | Myeloid cell nuclear differentiation antigen |
| Gene Name | MNDA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | QEKAPVKKINQEEVG |
| 121 | PAPTARNKLTSEARG |
| 135 | GRIPVAQKRKTPNKE |
| 275 | ISDYSECKGVMEIKE |
Function
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1
Protein Sequence
10
MVNEYKKILL
20
LKGFELMDDY
30
HFTSIKSLLA
40
YDLGLTTKMQ
50
EEYNRIKITD
60
LMEKKFQGVA
70
CLDKLIELAK
80
DMPSLKNLVN
90
NLRKEKSKVA
100
KKIKTQEKAP
110
VKKINQEEVG
120
LAAPAPTARN
130
KLTSEARGRI
140
PVAQKRKTPN
150
KEKTEAKRNK
160
VSQEQSKPPG
170
PSGASTSAAV
180
DHPPLPQTSS
190
STPSNTSFTP
200
NQETQAQRQV
210
DARRNVPQND
220
PVTVVVLKAT
230
APFKYESPEN
240
GKSTMFHATV
250
ASKTQYFHVK
260
VFDINLKEKF
270
VRKKVITISD
280
YSECKGVMEI
290
KEASSVSDFN
300
QNFEVPNRII
310
EIANKTPKIS
320
QLYKQASGTM
330
VYGLFMLQKK
340
SVHKKNTIYE
350
IQDNTGSMDV
360
VGSGKWHNIK
370
CEKGDKLRLF
380
CLQLRTVDRK
390
LKLVCGSHSF
400
IKVIKAKKNK
EGPMNVN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Biological Process | GO:0002218 | activation of innate immune response |
| Biological Process | GO:0050853 | B cell receptor signaling pathway |
| Biological Process | GO:0006968 | cellular defense response |
| Biological Process | GO:0035458 | cellular response to interferon-beta |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0030889 | negative regulation of B cell proliferation |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.