Search Results

Overview

Uniprot ID	P41229
Protein Name	Lysine-specific demethylase 5C
Gene Name	KDM5C
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
205	RQSVQPSKFNSYGRR
235	EKNPELKKLQIYGAG
307	HSPEPCTKMTMRLRR

Function

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity)

Protein Sequence

10 MEPGSDDFLP 20 PPECPVFEPS 30 WAEFRDPLGY 40 IAKIRPIAEK 50 SGICKIRPPA 60 DWQPPFAVEV 70 DNFRFTPRIQ 80 RLNELEAQTR 90 VKLNYLDQIA 100 KFWEIQGSSL 110 KIPNVERRIL 120 DLYSLSKIVV 130 EEGGYEAICK 140 DRRWARVAQR 150 LNYPPGKNIG 160 SLLRSHYERI 170 VYPYEMYQSG 180 ANLVQCNTRP 190 FDNEEKDKEY 200 KPHSIPLRQS 210 VQPSKFNSYG 220 RRAKRLQPDP 230 EPTEEDIEKN 240 PELKKLQIYG 250 AGPKMMGLGL 260 MAKDKTLRKK 270 DKEGPECPPT 280 VVVKEELGGD 290 VKVESTSPKT 300 FLESKEELSH 310 SPEPCTKMTM 320 RLRRNHSNAQ 330 FIESYVCRMC 340 SRGDEDDKLL 350 LCDGCDDNYH 360 IFCLLPPLPE 370 IPKGVWRCPK 380 CVMAECKRPP 390 EAFGFEQATR 400 EYTLQSFGEM 410 ADSFKADYFN 420 MPVHMVPTEL 430 VEKEFWRLVN 440 SIEEDVTVEY 450 GADIHSKEFG 460 SGFPVSDSKR 470 HLTPEEEEYA 480 TSGWNLNVMP 490 VLEQSVLCHI 500 NADISGMKVP 510 WLYVGMVFSA 520 FCWHIEDHWS 530 YSINYLHWGE 540 PKTWYGVPSL 550 AAEHLEEVMK 560 KLTPELFDSQ 570 PDLLHQLVTL 580 MNPNTLMSHG 590 VPVVRTNQCA 600 GEFVITFPRA 610 YHSGFNQGYN 620 FAEAVNFCTA 630 DWLPAGRQCI 640 EHYRRLRRYC 650 VFSHEELICK 660 MAACPEKLDL 670 NLAAAVHKEM 680 FIMVQEERRL 690 RKALLEKGIT 700 EAEREAFELL 710 PDDERQCIKC 720 KTTCFLSALA 730 CYDCPDGLVC 740 LSHINDLCKC 750 SSSRQYLRYR 760 YTLDELPAML 770 HKLKVRAESF 780 DTWANKVRVA 790 LEVEDGRKRS 800 LEELRALESE 810 ARERRFPNSE 820 LLQQLKNCLS 830 EAEACVSRAL 840 GLVSGQEAGP 850 HRVAGLQMTL 860 TELRAFLDQM 870 NNLPCAMHQI 880 GDVKGVLEQV 890 EAYQAEAREA 900 LASLPSSPGL 910 LQSLLERGRQ 920 LGVEVPEAQQ 930 LQRQVEQARW 940 LDEVKRTLAP 950 SARRGTLAVM 960 RGLLVAGASV 970 APSPAVDKAQ 980 AELQELLTIA 990 ERWEEKAHLC 1000 LEARQKHPPA 1010 TLEAIIREAE 1020 NIPVHLPNIQ 1030 ALKEALAKAR 1040 AWIADVDEIQ 1050 NGDHYPCLDD 1060 LEGLVAVGRD 1070 LPVGLEELRQ 1080 LELQVLTAHS 1090 WREKASKTFL 1100 KKNSCYTLLE 1110 VLCPCADAGS 1120 DSTKRSRWME 1130 KELGLYKSDT 1140 ELLGLSAQDL 1150 RDPGSVIVAF 1160 KEGEQKEKEG 1170 ILQLRRTNSA 1180 KPSPLASSST 1190 ASSTTSICVC 1200 GQVLAGAGAL 1210 QCDLCQDWFH 1220 GRCVSVPRLL 1230 SSPRPNPTSS 1240 PLLAWWEWDT 1250 KFLCPLCMRS 1260 RRPRLETILA 1270 LLVALQRLPV 1280 RLPEGEALQC 1290 LTERAISWQG 1300 RARQALASED 1310 VTALLGRLAE 1320 LRQRLQAEPR 1330 PEEPPNYPAA 1340 PASDPLREGS 1350 GKDMPKVQGL 1360 LENGDSVTSP 1370 EKVAPEEGSG 1380 KRDLELLSSL 1390 LPQLTGPVLE 1400 LPEATRAPLE 1410 ELMMEGDLLE 1420 VTLDENHSIW 1430 QLLQAGQPPD 1440 LERIRTLLEL 1450 EKAERHGSRA 1460 RGRALERRRR 1470 RKVDRGGEGD 1480 DPAREELEPK 1490 RVRSSGPEAE 1500 EVQEEEELEE 1510 ETGGEGPPAP 1520 IPTTGSPSTQ 1530 ENQNGLEPAE 1540 GTTSGPSAPF 1550 STLTPRLHLP 1560 CPQQPPQQQL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0032452	histone demethylase activity
Molecular Function	GO:0032453	histone H3K4 demethylase activity
Molecular Function	GO:0034647	histone H3K4me/H3K4me2/H3K4me3 demethylase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0048511	rhythmic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.