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Overview

Uniprot IDP41236
Protein NameProtein phosphatase inhibitor 2
Gene NamePPP1R2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 APDILARKLAAAEGL
113 AAEGLEPKYRIQEQE
12 TASHRPIKGILKNKT
145 RQFEMKRKLHYNEGL
155 YNEGLNIKLARQLIS
16 RPIKGILKNKTSTTS
18 IKGILKNKTSTTSSM
42 NVDEELSKKSQKWDE
43 VDEELSKKSQKWDEM
46 ELSKKSQKWDEMNIL

Function

Inhibitor of protein-phosphatase 1

Protein Sequence

10 MAASTASHRP 20 IKGILKNKTS 30 TTSSMVASAE 40 QPRGNVDEEL 50 SKKSQKWDEM 60 NILATYHPAD 70 KDYGLMKIDE 80 PSTPYHSMMG 90 DDEDACSDTE 100 ATEAMAPDIL 110 ARKLAAAEGL 120 EPKYRIQEQE 130 SSGEEDSDLS 140 PEEREKKRQF 150 EMKRKLHYNE 160 GLNIKLARQL 170 ISKDLHDDDE 180 DEEMLETADG 190 ESMNTEESNQ 200 GSTPSDQQQN KLRSS

Gene Ontology

Classification GO ID Description
Molecular Function GO:0140678 molecular function inhibitor activity
Molecular Function GO:0004864 protein phosphatase inhibitor activity
Molecular Function GO:0004865 protein serine/threonine phosphatase inhibitor activity
Biological Process GO:0006091 generation of precursor metabolites and energy
Biological Process GO:0005977 glycogen metabolic process
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0009966 regulation of signal transduction

Reference

[1] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.