Overview
| Uniprot ID | P41367 |
|---|
| Protein Name | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|
| Gene Name | ACADM |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 301 |
RALDEATKYALERKT |
Function
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3233192). The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA) (PubMed:3233192). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16 (By similarity)
Protein Sequence
10
MAAMFRRSCR
20
VLRSLSHFGW
30
RSQHTKAVPQ
40
CEPGSGFSFE
50
LTEQQKEFQA
60
TARKFAREEI
70
IPVAAEYDRT
80
GEYPVPLLKR
90
AWELGLMNTH
100
IPESFGGLGL
110
GIIDSCLITE
120
ELAYGCTGVQ
130
TAIEANTLGQ
140
VPLIIGGNYQ
150
QQKKYLGRMT
160
EEPLMCAYCV
170
TEPGAGSDVA
180
GIKTKAEKKG
190
DEYIINGQKM
200
WITNGGKANW
210
YFLLARSDPD
220
PKAPASKAFT
230
GFIVEADTPG
240
VQIGRKEINM
250
GQRCSDTRGI
260
VFEDVRVPKE
270
NVLTGEGAGF
280
KIAMGTFDKT
290
RPPVAAGAVG
300
LAQRALDEAT
310
KYALERKTFG
320
KLLAEHQGIS
330
FLLADMAMKV
340
ELARLSYQRA
350
AWEIDSGRRN
360
TYYASIAKAY
370
AADIANQLAT
380
DAVQVFGGNG
390
FNTEYPVEKL
400
MRDAKIYQIY
410
EGTAQIQRII
420
IAREHIGRYK
N
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Molecular Function |
GO:0003995 |
acyl-CoA dehydrogenase activity |
| Molecular Function |
GO:0050660 |
flavin adenine dinucleotide binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0070991 |
medium-chain fatty acyl-CoA dehydrogenase activity |
| Biological Process |
GO:0045329 |
carnitine biosynthetic process |
| Biological Process |
GO:0019254 |
carnitine metabolic process, CoA-linked |
| Biological Process |
GO:0006635 |
fatty acid beta-oxidation |
| Biological Process |
GO:0033539 |
fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| Biological Process |
GO:0005978 |
glycogen biosynthetic process |
| Biological Process |
GO:0051793 |
medium-chain fatty acid catabolic process |
| Biological Process |
GO:0006111 |
regulation of gluconeogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.