Search Results
Overview
| Uniprot ID | P41498 |
|---|---|
| Protein Name | Low molecular weight phosphotyrosine protein phosphatase |
| Gene Name | Acp1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | NRKSNQVKNCKAKIE |
| 113 | QVKNCKAKIELLGSY |
Function
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2
Protein Sequence
10
MAEVGSKSVL
20
FVCLGNICRS
30
PIAEAVFRKL
40
VTDENVSDNW
50
RIDSAATSTY
60
EVGNPPDYRG
70
QNCMKKHGIH
80
MQHIARQITR
90
EDFATFDYIL
100
CMDESNLRDL
110
NRKSNQVKNC
120
KAKIELLGSY
130
DPQKQLIIED
140
PYYGNDSDFE
150
VVYQQCLRCC
KAFLEKTH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003993 | acid phosphatase activity |
| Molecular Function | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| Molecular Function | GO:0016791 | phosphatase activity |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0007268 | chemical synaptic transmission |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.