Search Results
Overview
| Uniprot ID | P41499 |
|---|---|
| Protein Name | Tyrosine-protein phosphatase non-receptor type 11 |
| Gene Name | Ptpn11 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 538 | EEQKSKRKGHEYTNI |
Function
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (By similarity). Positively regulates MAPK signal transduction pathway (By similarity). Dephosphorylates GAB1, ARHGAP35 and EGFR (By similarity). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (By similarity). Dephosphorylates CDC73 (By similarity). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (By similarity). Acts as an effector of PDCD1-mediated inhibition of T-cell response: recruited by phosphorylated PDCD1, mediating dephosphorylation of key T-cell receptor (TCR) proximal signaling molecules, leading to TCR signaling inhibition (By similarity)
Protein Sequence
10
MTSRRWFHPN
20
ITGVEAENLL
30
LTRGVDGSFL
40
ARPSKSNPGD
50
FTLSVRRNGA
60
VTHIKIQNTG
70
DYYDLYGGEK
80
FATLAELVQY
90
YMEHHGQLKE
100
KNGDVIELKY
110
PLNCADPTSE
120
RWFHGHLSGK
130
EAEKLLTEKG
140
KHGSFLVRES
150
QSHPGDFVLS
160
VRTGDDKGES
170
NDSKSKVTHV
180
MIRCQELKYD
190
VGGGERFDSL
200
TDLVEHYKKN
210
PMVETLGTVL
220
QLKQPLNTTR
230
INAAEIESRV
240
RELSKLAETT
250
DKVKQGFWEE
260
FETLQQQECK
270
LLYSRKEGQR
280
QENKNKNRYK
290
NILPFDHTRV
300
VLHDGDPNEP
310
VSDYINANII
320
MPEFETKCNN
330
SKPKKSYIAT
340
QGCLQNTVND
350
FWRMVFQENS
360
RVIVMTTKEV
370
ERGKSKCVKY
380
WPDECALKEY
390
GVMRVRNVRE
400
SAAHDYTLRE
410
LKLSKVGQGN
420
TERTVWQYHF
430
RTWPDHGVPS
440
DPGGVLDFLE
450
EVHHKQESIV
460
DAGPVVVHCS
470
AGIGRTGTFI
480
VIDILIDIIR
490
EKGVDCDIDV
500
PKTIQMVRSQ
510
RSGMVQTEAQ
520
YRFIYMAVQH
530
YIETLQRRIE
540
EEQKSKRKGH
550
EYTNIKYSLV
560
DQTSGDQSPL
570
PPCTPTPPCA
580
EMREDSARVY
590
ENVGLMQQQR
SFR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0032528 | microvillus organization |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0050839 | cell adhesion molecule binding |
| Molecular Function | GO:0031748 | D1 dopamine receptor binding |
| Molecular Function | GO:0005158 | insulin receptor binding |
| Molecular Function | GO:0043560 | insulin receptor substrate binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| Molecular Function | GO:0051428 | peptide hormone receptor binding |
| Molecular Function | GO:0043274 | phospholipase binding |
| Molecular Function | GO:0004721 | phosphoprotein phosphatase activity |
| Molecular Function | GO:0001784 | phosphotyrosine residue binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:1990782 | protein tyrosine kinase binding |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Molecular Function | GO:0030159 | signaling receptor complex adaptor activity |
| Biological Process | GO:0036302 | atrioventricular canal development |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0060020 | Bergmann glial cell differentiation |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:1904385 | cellular response to angiotensin |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:1990314 | cellular response to insulin-like growth factor stimulus |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0021697 | cerebellar cortex formation |
| Biological Process | GO:0019221 | cytokine-mediated signaling pathway |
| Biological Process | GO:0000077 | DNA damage checkpoint signaling |
| Biological Process | GO:0048013 | ephrin receptor signaling pathway |
| Biological Process | GO:0007173 | epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0038127 | ERBB signaling pathway |
| Biological Process | GO:0060325 | face morphogenesis |
| Biological Process | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| Biological Process | GO:0048806 | genitalia development |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0048873 | homeostasis of number of cells within a tissue |
| Biological Process | GO:0042445 | hormone metabolic process |
| Biological Process | GO:0009755 | hormone-mediated signaling pathway |
| Biological Process | GO:0048839 | inner ear development |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0061582 | intestinal epithelial cell migration |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0035855 | megakaryocyte development |
| Biological Process | GO:0035264 | multicellular organism growth |
| Biological Process | GO:0033629 | negative regulation of cell adhesion mediated by integrin |
| Biological Process | GO:0032331 | negative regulation of chondrocyte differentiation |
| Biological Process | GO:0051463 | negative regulation of cortisol secretion |
| Biological Process | GO:0060125 | negative regulation of growth hormone secretion |
| Biological Process | GO:0046888 | negative regulation of hormone secretion |
| Biological Process | GO:0046676 | negative regulation of insulin secretion |
| Biological Process | GO:1902564 | negative regulation of neutrophil activation |
| Biological Process | GO:0050868 | negative regulation of T cell activation |
| Biological Process | GO:0042130 | negative regulation of T cell proliferation |
| Biological Process | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| Biological Process | GO:0032480 | negative regulation of type I interferon production |
| Biological Process | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| Biological Process | GO:0035265 | organ growth |
| Biological Process | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| Biological Process | GO:0030220 | platelet formation |
| Biological Process | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| Biological Process | GO:0046326 | positive regulation of D-glucose import across plasma membrane |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0051894 | positive regulation of focal adhesion assembly |
| Biological Process | GO:0046887 | positive regulation of hormone secretion |
| Biological Process | GO:0046628 | positive regulation of insulin receptor signaling pathway |
| Biological Process | GO:0032728 | positive regulation of interferon-beta production |
| Biological Process | GO:1902533 | positive regulation of intracellular signal transduction |
| Biological Process | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway |
| Biological Process | GO:0045931 | positive regulation of mitotic cell cycle |
| Biological Process | GO:0045778 | positive regulation of ossification |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0009967 | positive regulation of signal transduction |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0043408 | regulation of MAPK cascade |
| Biological Process | GO:0046825 | regulation of protein export from nucleus |
| Biological Process | GO:0043254 | regulation of protein-containing complex assembly |
| Biological Process | GO:0048659 | smooth muscle cell proliferation |
| Biological Process | GO:0006641 | triglyceride metabolic process |
| Biological Process | GO:0042311 | vasodilation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.