Search Results
Overview
| Uniprot ID | P41542 |
|---|---|
| Protein Name | General vesicular transport factor p115 |
| Gene Name | Uso1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 626 | ELEGVITKAIYKSSE |
Function
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane (PubMed:10679020, PubMed:7831323, PubMed:7831324). May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (PubMed:10679020, PubMed:7831323, PubMed:7831324)
Protein Sequence
10
MNFLRGVMGG
20
QSAGPQHTEA
30
ETIQKLCDRV
40
ASSTLLDDRR
50
NAVRALKSLS
60
KKYRLEVGIQ
70
AMEHLIHVLQ
80
TDRSDSEIIA
90
YALDTLYNII
100
SNDEEEEVEE
110
NSTRQSEDLG
120
SQFTEIFIKQ
130
PENVTLLLSL
140
LEEFDFHVRW
150
PGVRLLTSLL
160
KQLGPPVQQI
170
ILVSPMGVSK
180
LMDLLADSRE
190
IIRNDGVLLL
200
QALTRSNGAI
210
QKIVAFENAF
220
ERLLDIITEE
230
GNSDGGIVVE
240
DCLILLQNLL
250
KNNNSNQNFF
260
KEGSYIQRMK
270
AWFEVGDENP
280
GWSAQKVTNL
290
HLMLQLVRVL
300
VSPTNPPGAT
310
SSCQKAMFQC
320
GLLQQLCTIL
330
MATGIPADIL
340
TETINTVSEV
350
IRGCQVNQDY
360
FASVNAPSNP
370
PRPAIVVLLM
380
SMVNERQPFV
390
LRCAVLYCFQ
400
CFLYKNEKGQ
410
GEIVATLLPS
420
TIDATGNSVS
430
AGQLLCGGLF
440
STDSLSNWCA
450
AVALAHALQG
460
NATQKEQLLR
470
VQLATSIGNP
480
PVSLLQQCTN
490
ILSQGSKIQT
500
RVGLLMLLCT
510
WLSNCPIAVT
520
HFLHNSANVP
530
FLTGQIAENL
540
GEEEQLVQGL
550
CALLLGISIY
560
FNDNSLENYT
570
KEKLKQLIEK
580
RIGKENYIEK
590
LGFISKHELY
600
SRASQKPQPN
610
FPSPEYMIFD
620
HEFTKLVKEL
630
EGVITKAIYK
640
SSEEDKKEEE
650
VKKTLEQHDN
660
IVTHYKNMIR
670
EQDLQLEELK
680
QQVSTLKCQN
690
EQLQTAVTQQ
700
ASQIQQHKDQ
710
YNLLKVQLGK
720
DNHHQGSHSD
730
GAQVNGIQPE
740
EISRLREEIE
750
ELRSHQVLLQ
760
SQLAEKDTVI
770
ENLRSSQVSG
780
MSEQALATCS
790
PRDAEQVAEL
800
KQELSALKSQ
810
LCSQSLEITR
820
LQTENSELQQ
830
RAETLAKSVP
840
VEGESELVTA
850
AKTTDVEGRL
860
SALLQETKEL
870
KNEIKALSEE
880
RTAIQKQLDS
890
SNSTIAILQT
900
EKDKLYLEVT
910
DSKKEQDDLL
920
VLLADQDQKI
930
LSLKSKLKDL
940
GHPVEEEDES
950
GDQEDDDDEL
DDGDRDQDI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005795 | Golgi stack |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0007030 | Golgi organization |
| Biological Process | GO:0048211 | Golgi vesicle docking |
| Biological Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0061025 | membrane fusion |
| Biological Process | GO:1900076 | regulation of cellular response to insulin stimulus |
| Biological Process | GO:0032252 | secretory granule localization |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
| Biological Process | GO:0045056 | transcytosis |
| Biological Process | GO:0048280 | vesicle fusion with Golgi apparatus |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.