Search Results
Overview
| Uniprot ID | P41562 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NADP] cytoplasmic |
| Gene Name | Idh1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 236 | EIYDKQYKSKFEAQK |
Function
Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (By similarity). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)
Protein Sequence
10
MSRKIHGGSV
20
VEMQGDEMTR
30
IIWELIKEKL
40
ILPYVELDLH
50
SYDLGIENRD
60
ATNDQVTKDA
70
AEAIKKYNVG
80
VKCATITPDE
90
KRVEEFKLKQ
100
MWKSPNGTIR
110
NILGGTVFRE
120
AIICKNIPRL
130
VTGWVKPIII
140
GRHAYGDQYR
150
ATDFVVPGPG
160
KVEITYTPKD
170
GSQKVTYLVH
180
DFEEGGGVAM
190
GMYNQDKSIE
200
DFAHSSFQMA
210
LSKGWPLYLS
220
TKNTILKKYD
230
GRFKDIFQEI
240
YDKQYKSKFE
250
AQKIWYEHRL
260
IDDMVAQAMK
270
SEGGFIWACK
280
NYDGDVQSDS
290
VAQGYGSLGM
300
MTSVLICPDG
310
KTVEAEAAHG
320
TVTRHYRMYQ
330
KGQETSTNPI
340
ASIFAWSRGL
350
AHRAKLDNNT
360
ELSFFANALE
370
EVCIETIEAG
380
FMTKDLAACI
390
KGLPNVQRSD
400
YLNTFEFMDK
410
LGENLKAKLA
QAKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004450 | isocitrate dehydrogenase (NADP+) activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0050661 | NADP binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006103 | 2-oxoglutarate metabolic process |
| Biological Process | GO:0008585 | female gonad development |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0006097 | glyoxylate cycle |
| Biological Process | GO:0006102 | isocitrate metabolic process |
| Biological Process | GO:0006739 | NADP+ metabolic process |
| Biological Process | GO:0006740 | NADPH regeneration |
| Biological Process | GO:0071071 | regulation of phospholipid biosynthetic process |
| Biological Process | GO:0060696 | regulation of phospholipid catabolic process |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0048545 | response to steroid hormone |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.