Search Results
Overview
| Uniprot ID | P41594 |
|---|---|
| Protein Name | Metabotropic glutamate receptor 5 |
| Gene Name | GRM5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 851 | RMHVGDGKSSSAASR |
| 922 | VTWAQNEKSSRGQHL |
Function
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity
Protein Sequence
10
MVLLLILSVL
20
LLKEDVRGSA
30
QSSERRVVAH
40
MPGDIIIGAL
50
FSVHHQPTVD
60
KVHERKCGAV
70
REQYGIQRVE
80
AMLHTLERIN
90
SDPTLLPNIT
100
LGCEIRDSCW
110
HSAVALEQSI
120
EFIRDSLISS
130
EEEEGLVRCV
140
DGSSSSFRSK
150
KPIVGVIGPG
160
SSSVAIQVQN
170
LLQLFNIPQI
180
AYSATSMDLS
190
DKTLFKYFMR
200
VVPSDAQQAR
210
AMVDIVKRYN
220
WTYVSAVHTE
230
GNYGESGMEA
240
FKDMSAKEGI
250
CIAHSYKIYS
260
NAGEQSFDKL
270
LKKLTSHLPK
280
ARVVACFCEG
290
MTVRGLLMAM
300
RRLGLAGEFL
310
LLGSDGWADR
320
YDVTDGYQRE
330
AVGGITIKLQ
340
SPDVKWFDDY
350
YLKLRPETNH
360
RNPWFQEFWQ
370
HRFQCRLEGF
380
PQENSKYNKT
390
CNSSLTLKTH
400
HVQDSKMGFV
410
INAIYSMAYG
420
LHNMQMSLCP
430
GYAGLCDAMK
440
PIDGRKLLES
450
LMKTNFTGVS
460
GDTILFDENG
470
DSPGRYEIMN
480
FKEMGKDYFD
490
YINVGSWDNG
500
ELKMDDDEVW
510
SKKSNIIRSV
520
CSEPCEKGQI
530
KVIRKGEVSC
540
CWTCTPCKEN
550
EYVFDEYTCK
560
ACQLGSWPTD
570
DLTGCDLIPV
580
QYLRWGDPEP
590
IAAVVFACLG
600
LLATLFVTVV
610
FIIYRDTPVV
620
KSSSRELCYI
630
ILAGICLGYL
640
CTFCLIAKPK
650
QIYCYLQRIG
660
IGLSPAMSYS
670
ALVTKTNRIA
680
RILAGSKKKI
690
CTKKPRFMSA
700
CAQLVIAFIL
710
ICIQLGIIVA
720
LFIMEPPDIM
730
HDYPSIREVY
740
LICNTTNLGV
750
VTPLGYNGLL
760
ILSCTFYAFK
770
TRNVPANFNE
780
AKYIAFTMYT
790
TCIIWLAFVP
800
IYFGSNYKII
810
TMCFSVSLSA
820
TVALGCMFVP
830
KVYIILAKPE
840
RNVRSAFTTS
850
TVVRMHVGDG
860
KSSSAASRSS
870
SLVNLWKRRG
880
SSGETLRYKD
890
RRLAQHKSEI
900
ECFTPKGSMG
910
NGGRATMSSS
920
NGKSVTWAQN
930
EKSSRGQHLW
940
QRLSIHINKK
950
ENPNQTAVIK
960
PFPKSTESRG
970
LGAGAGAGGS
980
AGGVGATGGA
990
GCAGAGPGGP
1000
ESPDAGPKAL
1010
YDVAEAEEHF
1020
PAPARPRSPS
1030
PISTLSHRAG
1040
SASRTDDDVP
1050
SLHSEPVARS
1060
SSSQGSLMEQ
1070
ISSVVTRFTA
1080
NISELNSMML
1090
STAAPSPGVG
1100
APLCSSYLIP
1110
KEIQLPTTMT
1120
TFAEIQPLPA
1130
IEVTGGAQPA
1140
AGAQAAGDAA
1150
RESPAAGPEA
1160
AAAKPDLEEL
1170
VALTPPSPFR
1180
DSVDSGSTTP
1190
NSPVSESALC
1200
IPSSPKYDTL
1210
IIRDYTQSSS
SL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097449 | astrocyte projection |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0043278 | response to morphine |
| Biological Process | GO:0062036 | sensory perception of hot stimulus |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0001659 | temperature homeostasis |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005637 | nuclear inner membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Molecular Function | GO:0031687 | A2A adenosine receptor binding |
| Molecular Function | GO:0001640 | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity |
| Molecular Function | GO:0004930 | G protein-coupled receptor activity |
| Molecular Function | GO:0099530 | G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential |
| Molecular Function | GO:0008066 | glutamate receptor activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration |
| Molecular Function | GO:0030296 | protein tyrosine kinase activator activity |
| Molecular Function | GO:1990782 | protein tyrosine kinase binding |
| Biological Process | GO:1904646 | cellular response to amyloid-beta |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0050890 | cognition |
| Biological Process | GO:1990708 | conditioned place preference |
| Biological Process | GO:0002029 | desensitization of G protein-coupled receptor signaling pathway |
| Biological Process | GO:0007216 | G protein-coupled glutamate receptor signaling pathway |
| Biological Process | GO:0007611 | learning or memory |
| Biological Process | GO:0061002 | negative regulation of dendritic spine morphogenesis |
| Biological Process | GO:0090394 | negative regulation of excitatory postsynaptic potential |
| Biological Process | GO:0035106 | operant conditioning |
| Biological Process | GO:0007206 | phospholipase C-activating G protein-coupled glutamate receptor signaling pathway |
| Biological Process | GO:0050850 | positive regulation of calcium-mediated signaling |
| Biological Process | GO:1900039 | positive regulation of cellular response to hypoxia |
| Biological Process | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0033603 | positive regulation of dopamine secretion |
| Biological Process | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:2000179 | positive regulation of neural precursor cell proliferation |
| Biological Process | GO:1904058 | positive regulation of sensory perception of pain |
| Biological Process | GO:0036228 | protein localization to nuclear inner membrane |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:1900452 | regulation of long-term synaptic depression |
| Biological Process | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0046677 | response to antibiotic |
| Biological Process | GO:0051412 | response to corticosterone |
Reference
[1] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.