Search Results

Overview

Uniprot IDP41743
Protein NameProtein kinase C iota type
Gene NamePRKCI
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
244 MNTRESGKASSSLGL

Function

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity)

Protein Sequence

10 MPTQRDSSTM 20 SHTVAGGGSG 30 DHSHQVRVKA 40 YYRGDIMITH 50 FEPSISFEGL 60 CNEVRDMCSF 70 DNEQLFTMKW 80 IDEEGDPCTV 90 SSQLELEEAF 100 RLYELNKDSE 110 LLIHVFPCVP 120 ERPGMPCPGE 130 DKSIYRRGAR 140 RWRKLYCANG 150 HTFQAKRFNR 160 RAHCAICTDR 170 IWGLGRQGYK 180 CINCKLLVHK 190 KCHKLVTIEC 200 GRHSLPQEPV 210 MPMDQSSMHS 220 DHAQTVIPYN 230 PSSHESLDQV 240 GEEKEAMNTR 250 ESGKASSSLG 260 LQDFDLLRVI 270 GRGSYAKVLL 280 VRLKKTDRIY 290 AMKVVKKELV 300 NDDEDIDWVQ 310 TEKHVFEQAS 320 NHPFLVGLHS 330 CFQTESRLFF 340 VIEYVNGGDL 350 MFHMQRQRKL 360 PEEHARFYSA 370 EISLALNYLH 380 ERGIIYRDLK 390 LDNVLLDSEG 400 HIKLTDYGMC 410 KEGLRPGDTT 420 STFCGTPNYI 430 APEILRGEDY 440 GFSVDWWALG 450 VLMFEMMAGR 460 SPFDIVGSSD 470 NPDQNTEDYL 480 FQVILEKQIR 490 IPRSLSVKAA 500 SVLKSFLNKD 510 PKERLGCHPQ 520 TGFADIQGHP 530 FFRNVDWDMM 540 EQKQVVPPFK 550 PNISGEFGLD 560 NFDSQFTNEP 570 VQLTPDDDDI 580 VRKIDQSEFE 590 GFEYINPLLM SAEECV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Biological Process GO:0045216 cell-cell junction organization
Biological Process GO:0062197 cellular response to chemical stress
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0030010 establishment of cell polarity
Biological Process GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Biological Process GO:0048194 Golgi vesicle budding
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0061024 membrane organization
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0034351 negative regulation of glial cell apoptotic process
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0046326 positive regulation of D-glucose import across plasma membrane
Biological Process GO:2000353 positive regulation of endothelial cell apoptotic process
Biological Process GO:0060252 positive regulation of glial cell proliferation
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0045747 positive regulation of Notch signaling pathway
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
Biological Process GO:0070555 response to interleukin-1
Biological Process GO:0046903 secretion
Biological Process GO:0016192 vesicle-mediated transport
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0005903 brush border
Cellular Component GO:0031252 cell leading edge
Cellular Component GO:0005929 cilium
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005768 endosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0043220 Schmidt-Lanterman incisure
Cellular Component GO:0070160 tight junction
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0004672 protein kinase activity
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0016477 cell migration

Reference

PMID: N/A