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Overview

Uniprot IDP41777
Protein NameNucleolar and coiled-body phosphoprotein 1
Gene NameNolc1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
120 SLPQHAGKAAAKASE
158 KAVKPQAKAVRPPPK
204 APTKAQTKAPAKPGP
261 PKKQVVAKAPVKVTA
357 PAKTVVSKTPAKPAP
410 TPKPPAAKAVATPKQ
455 KKSVTTPKARVTAKA
461 PKARVTAKAAPSLPA
469 AAPSLPAKQAPRAGG
502 PKPPAKKKAAGAAVP
652 ADNSFDAKRGAAGDW
668 ERANQVLKFTKGKSF

Function

Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities

Protein Sequence

10 MADTGLRRVV 20 PSDLYPLVLG 30 FLRDNQLSEV 40 ASKFAKATGA 50 TQQDANASSL 60 LDIYSFWLKS 70 TKAPKVKLQS 80 NGPVAKKAKK 90 ETSSSDSSED 100 SSEEEDKAQV 110 PTQKAAAPAK 120 RASLPQHAGK 130 AAAKASESSS 140 SEESSEEEEE 150 EDKKKKPVQQ 160 KAVKPQAKAV 170 RPPPKKAESS 180 ESESDSSSED 190 EAPQTQKPKA 200 AATAAKAPTK 210 AQTKAPAKPG 220 PPAKAQPKAA 230 NGKAGSSSSS 240 SSSSSSDDSE 250 EEKKAAAPLK 260 KTAPKKQVVA 270 KAPVKVTAAP 280 TQKSSSSEDS 290 SSEEEEEQKK 300 PMKKKAGPYS 310 SVPPPSVSLS 320 KKSVGAQSPK 330 KAAAQTQPAD 340 SSADSSEESD 350 SSSEEEKKTP 360 AKTVVSKTPA 370 KPAPVKKKAE 380 SSSDSSDSDS 390 SEDEAPAKPV 400 SATKSPLSKP 410 AVTPKPPAAK 420 AVATPKQPAG 430 SGQKPQSRKA 440 DSSSSEEESS 450 SSEEEATKKS 460 VTTPKARVTA 470 KAAPSLPAKQ 480 APRAGGDSSS 490 DSESSSSEEE 500 KKTPPKPPAK 510 KKAAGAAVPK 520 PTPVKKAAAE 530 SSSSSSSSED 540 SSEEEKKKPK 550 SKATPKPQAG 560 KANGVPASQN 570 GKAGKESEEE 580 EEDTEQNKKA 590 AGTKPGSGKK 600 RKHNETADEA 610 ATPQSKKVKL 620 QTPNTFPKRK 630 KGEKRASSPF 640 RRVREEEIEV 650 DSRVADNSFD 660 AKRGAAGDWG 670 ERANQVLKFT 680 KGKSFRHEKT 690 KKKRGSYRGG 700 SISVQVNSVK FDSE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031428 box C/D methylation guide snoRNP complex
Cellular Component GO:0031429 box H/ACA snoRNP complex
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0062064 box C/D methylation guide snoRNP complex binding
Molecular Function GO:0034512 box C/D sno(s)RNA binding
Molecular Function GO:0034513 box H/ACA snoRNA binding
Molecular Function GO:0062065 box H/ACA snoRNP complex binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0140678 molecular function inhibitor activity
Molecular Function GO:0008139 nuclear localization sequence binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0004860 protein kinase inhibitor activity
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0001093 TFIIB-class transcription factor binding
Biological Process GO:0007409 axonogenesis
Biological Process GO:0033979 box H/ACA sno(s)RNA metabolic process
Biological Process GO:0071901 negative regulation of protein serine/threonine kinase activity
Biological Process GO:0014032 neural crest cell development
Biological Process GO:0014029 neural crest formation
Biological Process GO:0007000 nucleolus organization
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0042306 regulation of protein import into nucleus
Biological Process GO:0048167 regulation of synaptic plasticity
Biological Process GO:0006417 regulation of translation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.