Search Results
Overview
| Uniprot ID | P42123 |
|---|---|
| Protein Name | L-lactate dehydrogenase B chain |
| Gene Name | Ldhb |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 156 | WKLSGLPKHRVIGSG |
| 233 | ENWKEVHKMVVDSAY |
| 308 | LTSVINQKLKDDEVA |
| 310 | SVINQKLKDDEVAQL |
| 319 | DEVAQLRKSADTLWD |
| 7 | *MATLKEKLIAPVAD |
| 82 | TPKIVADKDYSVTAN |
Function
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)
Protein Sequence
10
MATLKEKLIA
20
PVADDETAVP
30
NNKITVVGVG
40
QVGMACAISI
50
LGKSLADELA
60
LVDVLEDKLK
70
GEMMDLQHGS
80
LFLQTPKIVA
90
DKDYSVTANS
100
KIVVVTAGVR
110
QQEGESRLNL
120
VQRNVNVFKF
130
IIPQIVKYSP
140
DCTIIVVSNP
150
VDILTYVTWK
160
LSGLPKHRVI
170
GSGCNLDSAR
180
FRYLMAEKLG
190
IHPSSCHGWI
200
LGEHGDSSVA
210
VWSGVNVAGV
220
SLQELNPEMG
230
TDNDSENWKE
240
VHKMVVDSAY
250
EVIKLKGYTN
260
WAIGLSVADL
270
IESMLKNLSR
280
IHPVSTMVKG
290
MYGIENEVFL
300
SLPCILNARG
310
LTSVINQKLK
320
DDEVAQLRKS
330
ADTLWDIQKD
LKDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:1990204 | oxidoreductase complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0004459 | L-lactate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0004457 | lactate dehydrogenase activity |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0006089 | lactate metabolic process |
| Biological Process | GO:0019674 | NAD+ metabolic process |
| Biological Process | GO:0042867 | pyruvate catabolic process |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.