Search Results

Overview

Uniprot IDP42167
Protein NameLamina-associated polypeptide 2, isoforms beta/gamma
Gene NameTMPO
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
17 VLTKDKLKSELVANN
195 EDSKIELKLEKREPL
198 KIELKLEKREPLKGR
203 LEKREPLKGRAKTPV
207 EPLKGRAKTPVTLKQ
213 AKTPVTLKQRRVEHN
239 EWTSGSSKGGPLQAL
260 GSRRTPRKRVETSEH
303 NRVTGNFKHASPILP
323 DIPRRAPKKPLTRAE
334 TRAEVGEKTEERRVE
389 MEESFSSKYVPKYVP
393 FSSKYVPKYVPLADV
401 YVPLADVKSEKTKKG
60 LPAGTNSKGPPDFSS

Function

May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95

Protein Sequence

10 MPEFLEDPSV 20 LTKDKLKSEL 30 VANNVTLPAG 40 EQRKDVYVQL 50 YLQHLTARNR 60 PPLPAGTNSK 70 GPPDFSSDEE 80 REPTPVLGSG 90 AAAAGRSRAA 100 VGRKATKKTD 110 KPRQEDKDDL 120 DVTELTNEDL 130 LDQLVKYGVN 140 PGPIVGTTRK 150 LYEKKLLKLR 160 EQGTESRSST 170 PLPTISSSAE 180 NTRQNGSNDS 190 DRYSDNEEDS 200 KIELKLEKRE 210 PLKGRAKTPV 220 TLKQRRVEHN 230 QSYSQAGITE 240 TEWTSGSSKG 250 GPLQALTRES 260 TRGSRRTPRK 270 RVETSEHFRI 280 DGPVISESTP 290 IAETIMASSN 300 ESLVVNRVTG 310 NFKHASPILP 320 ITEFSDIPRR 330 APKKPLTRAE 340 VGEKTEERRV 350 ERDILKEMFP 360 YEASTPTGIS 370 ASCRRPIKGA 380 AGRPLELSDF 390 RMEESFSSKY 400 VPKYVPLADV 410 KSEKTKKGRS 420 IPVWIKILLF 430 VVVAVFLFLV 440 YQAMETNQVN 450 PFSNFLHVDP RKSN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005637 nuclear inner membrane
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0005521 lamin binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.