Search Results

Overview

Uniprot IDP42174
Protein NameGlutamate dehydrogenase 1, mitochondrial
Gene NameGLUD1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
147 SQHRTPCKGGIRYST
187 GGAKAGVKINPKNYT
191 AGVKINPKNYTDNEL
200 YTDNELEKITRRFTM
211 RFTMELAKKGFIGPG
363 GTILGFPKAKIYEGS
399 NAPRVKAKIIAEGAN
457 SYGRLTFKYERDSNY
480 SLERKFGKHGGTIPI
503 RISGASEKDIVHSGL
90 DKLVEDLKTRESEEQ
98 TRESEEQKRNRVRGI

Function

Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:8240242). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity)

Protein Sequence

10 MYRCLGEALL 20 LSRAGPAALG 30 SAAADSAALL 40 GRTRGQPATA 50 PQPGLAPPAR 60 RHYSEAAADR 70 EDDPNFFKMV 80 EGFFDRGASI 90 VEDKLVEDLK 100 TRESEEQKRN 110 RVRGILRIIK 120 PCNHVLSLSF 130 PIRRDDGSWE 140 VIEGYRAQHS 150 QHRTPCKGGI 160 RYSTDVSVDE 170 VKALASLMTY 180 KCAVVDVPFG 190 GAKAGVKINP 200 KNYTDNELEK 210 ITRRFTMELA 220 KKGFIGPGID 230 VPAPDMSTGE 240 REMSWIADTY 250 ASTIGHYDIN 260 AHACVTGKPI 270 SQGGIHGRIS 280 ATGRGVFHGI 290 ENFINEASYM 300 SILGMTPGFG 310 DKTFVVQGFG 320 NVGLHSMRYL 330 HRFGAKCVGV 340 GESDGSIWNP 350 DGIDPKELED 360 FKLQHGTILG 370 FPKAKIYEGS 380 ILEADCDILI 390 PAASEKQLTK 400 SNAPRVKAKI 410 IAEGANGPTT 420 PEADKIFLER 430 NIMVIPDLYL 440 NAGGVTVSYF 450 EWLKNLNHVS 460 YGRLTFKYER 470 DSNYHLLMSV 480 QESLERKFGK 490 HGGTIPIVPT 500 AEFQDRISGA 510 SEKDIVHSGL 520 AYTMERSARQ 530 IMRTAMKYNL 540 GLDLRTAAYV 550 NAIEKVFKVY NEAGVTFT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004352 glutamate dehydrogenase (NAD+) activity
Molecular Function GO:0004354 glutamate dehydrogenase (NADP+) activity
Molecular Function GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
Molecular Function GO:0005525 GTP binding
Biological Process GO:0006541 glutamine metabolic process
Biological Process GO:0006538 L-glutamate catabolic process
Biological Process GO:0072350 tricarboxylic acid metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.