Search Results

Overview

Uniprot IDP42226
Protein NameSignal transducer and activator of transcription 6
Gene NameSTAT6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 QILQGEKKAVMEQFR

Function

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling

Protein Sequence

10 MSLWGLVSKM 20 PPEKVQRLYV 30 DFPQHLRHLL 40 GDWLESQPWE 50 FLVGSDAFCC 60 NLASALLSDT 70 VQHLQASVGE 80 QGEGSTILQH 90 ISTLESIYQR 100 DPLKLVATFR 110 QILQGEKKAV 120 MEQFRHLPMP 130 FHWKQEELKF 140 KTGLRRLQHR 150 VGEIHLLREA 160 LQKGAEAGQV 170 SLHSLIETPA 180 NGTGPSEALA 190 MLLQETTGEL 200 EAAKALVLKR 210 IQIWKRQQQL 220 AGNGAPFEES 230 LAPLQERCES 240 LVDIYSQLQQ 250 EVGAAGGELE 260 PKTRASLTGR 270 LDEVLRTLVT 280 SCFLVEKQPP 290 QVLKTQTKFQ 300 AGVRFLLGLR 310 FLGAPAKPPL 320 VRADMVTEKQ 330 ARELSVPQGP 340 GAGAESTGEI 350 INNTVPLENS 360 IPGNCCSALF 370 KNLLLKKIKR 380 CERKGTESVT 390 EEKCAVLFSA 400 SFTLGPGKLP 410 IQLQALSLPL 420 VVIVHGNQDN 430 NAKATILWDN 440 AFSEMDRVPF 450 VVAERVPWEK 460 MCETLNLKFM 470 AEVGTNRGLL 480 PEHFLFLAQK 490 IFNDNSLSME 500 AFQHRSVSWS 510 QFNKEILLGR 520 GFTFWQWFDG 530 VLDLTKRCLR 540 SYWSDRLIIG 550 FISKQYVTSL 560 LLNEPDGTFL 570 LRFSDSEIGG 580 ITIAHVIRGQ 590 DGSPQIENIQ 600 PFSAKDLSIR 610 SLGDRIRDLA 620 QLKNLYPKKP 630 KDEAFRSHYK 640 PEQMGKDGRG 650 YVPATIKMTV 660 ERDQPLPTPE 670 LQMPTMVPSY 680 DLGMAPDSSM 690 SMQLGPDMVP 700 QVYPPHSHSI 710 PPYQGLSPEE 720 SVNVLSAFQE 730 PHLQMPPSLG 740 QMSLPFDQPH 750 PQGLLPCQPQ 760 EHAVSSPDPL 770 LCSDVTMVED 780 SCLSQPVTAF 790 PQGTWIGEDI 800 FPPLLPPTEQ 810 DLTKLLLEGQ 820 GESGGGSLGA 830 QPLLQPSHYG 840 QSGISMSHMD LRANPSW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019903 protein phosphatase binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0001223 transcription coactivator binding
Biological Process GO:0007259 cell surface receptor signaling pathway via JAK-STAT
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0006952 defense response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
Biological Process GO:0035771 interleukin-4-mediated signaling pathway
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0043434 response to peptide hormone

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.