Search Results
Overview
| Uniprot ID | P42357 |
|---|---|
| Protein Name | Histidine ammonia-lyase |
| Gene Name | HAL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 131 | EDLVNLGKGRYKIKL |
| 144 | KLTPTAEKRVQKSRE |
| 158 | EVIDSIIKEKTVVYG |
| 160 | IDSIIKEKTVVYGIT |
| 172 | GITTGFGKFARTVIP |
| 182 | RTVIPINKLQELQVN |
| 200 | SHSSGVGKPLSPERC |
| 293 | VLEAHGLKPVILKPK |
| 346 | EVLKGTTKAFDTDIH |
| 37 | EAVRRYIKNKPDNGG |
| 622 | VAAPYIEKYRMEHIP |
| 647 | SLQFLHKKSTKIPES |
| 650 | FLHKKSTKIPESEDL |
Function
No function data available.
Protein Sequence
10
MPRYTVHVRG
20
EWLAVPCQDA
30
QLTVGWLGRE
40
AVRRYIKNKP
50
DNGGFTSVDD
60
AHFLVRRCKG
70
LGLLDNEDRL
80
EVALENNEFV
90
EVVIEGDAMS
100
PDFIPSQPEG
110
VYLYSKYREP
120
EKYIELDGDR
130
LTTEDLVNLG
140
KGRYKIKLTP
150
TAEKRVQKSR
160
EVIDSIIKEK
170
TVVYGITTGF
180
GKFARTVIPI
190
NKLQELQVNL
200
VRSHSSGVGK
210
PLSPERCRML
220
LALRINVLAK
230
GYSGISLETL
240
KQVIEMFNAS
250
CLPYVPEKGT
260
VGASGDLAPL
270
SHLALGLVGE
280
GKMWSPKSGW
290
ADAKYVLEAH
300
GLKPVILKPK
310
EGLALINGTQ
320
MITSLGCEAV
330
ERASAIARQA
340
DIVAALTLEV
350
LKGTTKAFDT
360
DIHALRPHRG
370
QIEVAFRFRS
380
LLDSDHHPSE
390
IAESHRFCDR
400
VQDAYTLRCC
410
PQVHGVVNDT
420
IAFVKNIITT
430
ELNSATDNPM
440
VFANRGETVS
450
GGNFHGEYPA
460
KALDYLAIGI
470
HELAAISERR
480
IERLCNPSLS
490
ELPAFLVAEG
500
GLNSGFMIAH
510
CTAAALVSEN
520
KALCHPSSVD
530
SLSTSAATED
540
HVSMGGWAAR
550
KALRVIEHVE
560
QVLAIELLAA
570
CQGIEFLRPL
580
KTTTPLEKVY
590
DLVRSVVRPW
600
IKDRFMAPDI
610
EAAHRLLLEQ
620
KVWEVAAPYI
630
EKYRMEHIPE
640
SRPLSPTAFS
650
LQFLHKKSTK
IPESEDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004397 | histidine ammonia-lyase activity |
| Biological Process | GO:0006548 | L-histidine catabolic process |
| Biological Process | GO:0019556 | L-histidine catabolic process to glutamate and formamide |
| Biological Process | GO:0019557 | L-histidine catabolic process to glutamate and formate |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.