Search Results

Overview

Uniprot IDP42684
Protein NameTyrosine-protein kinase ABL2
Gene NameABL2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
578 RLPILPSKTRTLKKQ
809 PRNCQRSKLQLERTV

Function

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity)

Protein Sequence

10 MGQQVGRVGE 20 APGLQQPQPR 30 GIRGSSAARP 40 SGRRRDPAGR 50 TTETGFNIFT 60 QHDHFASCVE 70 DGFEGDKTGG 80 SSPEALHRPY 90 GCDVEPQALN 100 EAIRWSSKEN 110 LLGATESDPN 120 LFVALYDFVA 130 SGDNTLSITK 140 GEKLRVLGYN 150 QNGEWSEVRS 160 KNGQGWVPSN 170 YITPVNSLEK 180 HSWYHGPVSR 190 SAAEYLLSSL 200 INGSFLVRES 210 ESSPGQLSIS 220 LRYEGRVYHY 230 RINTTADGKV 240 YVTAESRFST 250 LAELVHHHST 260 VADGLVTTLH 270 YPAPKCNKPT 280 VYGVSPIHDK 290 WEMERTDITM 300 KHKLGGGQYG 310 EVYVGVWKKY 320 SLTVAVKTLK 330 EDTMEVEEFL 340 KEAAVMKEIK 350 HPNLVQLLGV 360 CTLEPPFYIV 370 TEYMPYGNLL 380 DYLRECNREE 390 VTAVVLLYMA 400 TQISSAMEYL 410 EKKNFIHRDL 420 AARNCLVGEN 430 HVVKVADFGL 440 SRLMTGDTYT 450 AHAGAKFPIK 460 WTAPESLAYN 470 TFSIKSDVWA 480 FGVLLWEIAT 490 YGMSPYPGID 500 LSQVYDLLEK 510 GYRMEQPEGC 520 PPKVYELMRA 530 CWKWSPADRP 540 SFAETHQAFE 550 TMFHDSSISE 560 EVAEELGRAA 570 SSSSVVPYLP 580 RLPILPSKTR 590 TLKKQVENKE 600 NIEGAQDATE 610 NSASSLAPGF 620 IRGAQASSGS 630 PALPRKQRDK 640 SPSSLLEDAK 650 ETCFTRDRKG 660 GFFSSFMKKR 670 NAPTPPKRSS 680 SFREMENQPH 690 KKYELTGNFS 700 SVASLQHADG 710 FSFTPAQQEA 720 NLVPPKCYGG 730 SFAQRNLCND 740 DGGGGGGSGT 750 AGGGWSGITG 760 FFTPRLIKKT 770 LGLRAGKPTA 780 SDDTSKPFPR 790 SNSTSSMSSG 800 LPEQDRMAMT 810 LPRNCQRSKL 820 QLERTVSTSS 830 QPEENVDRAN 840 DMLPKKSEES 850 AAPSRERPKA 860 KLLPRGATAL 870 PLRTPSGDLA 880 ITEKDPPGVG 890 VAGVAAAPKG 900 KEKNGGARLG 910 MAGVPEDGEQ 920 PGWPSPAKAA 930 PVLPTTHNHK 940 VPVLISPTLK 950 HTPADVQLIG 960 TDSQGNKFKL 970 LSEHQVTSSG 980 DKDRPRRVKP 990 KCAPPPPPVM 1000 RLLQHPSICS 1010 DPTEEPTALT 1020 AGQSTSETQE 1030 GGKKAALGAV 1040 PISGKAGRPV 1050 MPPPQVPLPT 1060 SSISPAKMAN 1070 GTAGTKVALR 1080 KTKQAAEKIS 1090 ADKISKEALL 1100 ECADLLSSAL 1110 TEPVPNSQLV 1120 DTGHQLLDYC 1130 SGYVDCIPQT 1140 RNKFAFREAV 1150 SKLELSLQEL 1160 QVSSAAAGVP 1170 GTNPVLNNLL 1180 SCVQEISDVV QR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:2000406 positive regulation of T cell migration
Biological Process GO:0036211 protein modification process
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0010506 regulation of autophagy
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:2000145 regulation of cell motility
Biological Process GO:0030100 regulation of endocytosis
Biological Process GO:0007165 signal transduction
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0003785 actin monomer binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0008047 enzyme activator activity
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0030145 manganese ion binding
Molecular Function GO:0004715 non-membrane spanning protein tyrosine kinase activity
Molecular Function GO:0001784 phosphotyrosine residue binding
Molecular Function GO:0004672 protein kinase activity
Molecular Function GO:0004713 protein tyrosine kinase activity
Biological Process GO:0007155 cell adhesion
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0071300 cellular response to retinoic acid
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0035640 exploration behavior
Biological Process GO:0035024 negative regulation of Rho protein signal transduction
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:1903905 positive regulation of establishment of T cell polarity

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.