Search Results

Overview

Uniprot IDP42704
Protein NameLeucine-rich PPR motif-containing protein, mitochondrial
Gene NameLRPPRC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 IPKKLLQKVFNDTCR
1098 AFAETHIKGFTLNDA
1128 KEAVTTLKTVLDQQQ
1332 MKSYVSEKDVTSAKA
1338 EKDVTSAKALYEHLT
1347 LYEHLTAKNTKLDDL
287 KGDIDHVKQTLEKVE
295 QTLEKVEKSELHLMD
463 QGIIEILKGMQELGV
613 QYFHQLEKMNVKIPE
750 SAVLDTGKYVGLVRV
868 VLCKLVEKGETDLIQ

Function

May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101)

Protein Sequence

10 MAALLRSARW 20 LLRAGAAPRL 30 PLSLRLLPGG 40 PGRLHAASYL 50 PAARAGPVAG 60 GLLSPARLYA 70 IAAKEKDIQE 80 ESTFSSRKIS 90 NQFDWALMRL 100 DLSVRRTGRI 110 PKKLLQKVFN 120 DTCRSGGLGG 130 SHALLLLRSC 140 GSLLPELKLE 150 ERTEFAHRIW 160 DTLQKLGAVY 170 DVSHYNALLK 180 VYLQNEYKFS 190 PTDFLAKMEE 200 ANIQPNRVTY 210 QRLIASYCNV 220 GDIEGASKIL 230 GFMKTKDLPV 240 TEAVFSALVT 250 GHARAGDMEN 260 AENILTVMRD 270 AGIEPGPDTY 280 LALLNAYAEK 290 GDIDHVKQTL 300 EKVEKSELHL 310 MDRDLLQIIF 320 SFSKAGYPQY 330 VSEILEKVTC 340 ERRYIPDAMN 350 LILLLVTEKL 360 EDVALQILLA 370 CPVSKEDGPS 380 VFGSFFLQHC 390 VTMNTPVEKL 400 TDYCKKLKEV 410 QMHSFPLQFT 420 LHCALLANKT 430 DLAKALMKAV 440 KEEGFPIRPH 450 YFWPLLVGRR 460 KEKNVQGIIE 470 ILKGMQELGV 480 HPDQETYTDY 490 VIPCFDSVNS 500 ARAILQENGC 510 LSDSDMFSQA 520 GLRSEAANGN 530 LDFVLSFLKS 540 NTLPISLQSI 550 RSSLLLGFRR 560 SMNINLWSEI 570 TELLYKDGRY 580 CQEPRGPTEA 590 VGYFLYNLID 600 SMSDSEVQAK 610 EEHLRQYFHQ 620 LEKMNVKIPE 630 NIYRGIRNLL 640 ESYHVPELIK 650 DAHLLVESKN 660 LDFQKTVQLT 670 SSELESTLET 680 LKAENQPIRD 690 VLKQLILVLC 700 SEENMQKALE 710 LKAKYESDMV 720 TGGYAALINL 730 CCRHDKVEDA 740 LNLKEEFDRL 750 DSSAVLDTGK 760 YVGLVRVLAK 770 HGKLQDAINI 780 LKEMKEKDVL 790 IKDTTALSFF 800 HMLNGAALRG 810 EIETVKQLHE 820 AIVTLGLAEP 830 STNISFPLVT 840 VHLEKGDLST 850 ALEVAIDCYE 860 KYKVLPRIHD 870 VLCKLVEKGE 880 TDLIQKAMDF 890 VSQEQGEMVM 900 LYDLFFAFLQ 910 TGNYKEAKKI 920 IETPGIRARS 930 ARLQWFCDRC 940 VANNQVETLE 950 KLVELTQKLF 960 ECDRDQMYYN 970 LLKLYKINGD 980 WQRADAVWNK 990 IQEENVIPRE 1000 KTLRLLAEIL 1010 REGNQEVPFD 1020 VPELWYEDEK 1030 HSLNSSSAST 1040 TEPDFQKDIL 1050 IACRLNQKKG 1060 AYDIFLNAKE 1070 QNIVFNAETY 1080 SNLIKLLMSE 1090 DYFTQAMEVK 1100 AFAETHIKGF 1110 TLNDAANSRL 1120 IITQVRRDYL 1130 KEAVTTLKTV 1140 LDQQQTPSRL 1150 AVTRVIQALA 1160 MKGDVENIEV 1170 VQKMLNGLED 1180 SIGLSKMVFI 1190 NNIALAQIKN 1200 NNIDAAIENI 1210 ENMLTSENKV 1220 IEPQYFGLAY 1230 LFRKVIEEQL 1240 EPAVEKISIM 1250 AERLANQFAI 1260 YKPVTDFFLQ 1270 LVDAGKVDDA 1280 RALLQRCGAI 1290 AEQTPILLLF 1300 LLRNSRKQGK 1310 ASTVKSVLEL 1320 IPELNEKEEA 1330 YNSLMKSYVS 1340 EKDVTSAKAL 1350 YEHLTAKNTK 1360 LDDLFLKRYA 1370 SLLKYAGEPV 1380 PFIEPPESFE 1390 FYAQQLRKLR ENSS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0042645 mitochondrial nucleoid
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005637 nuclear inner membrane
Cellular Component GO:0005640 nuclear outer membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0048487 beta-tubulin binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003730 mRNA 3'-UTR binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003697 single-stranded DNA binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0006914 autophagy
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0097222 mitochondrial mRNA polyadenylation
Biological Process GO:0047497 mitochondrion transport along microtubule
Biological Process GO:0051028 mRNA transport
Biological Process GO:1905638 negative regulation of mitochondrial mRNA catabolic process
Biological Process GO:0070129 regulation of mitochondrial translation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.