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Overview

Uniprot IDP42858
Protein NameHuntingtin
Gene NameHTT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
442 LSRKQKGKVLLGEEE

Function

May play a role in microtubule-mediated transport or vesicle function

Protein Sequence

10 MATLEKLMKA 20 FESLKSFQQQ 30 QQQQQQQQQQ 40 QQQQQQQQPP 50 PPPPPPPPPQ 60 LPQPPPQAQP 70 LLPQPQPPPP 80 PPPPPPGPAV 90 AEEPLHRPKK 100 ELSATKKDRV 110 NHCLTICENI 120 VAQSVRNSPE 130 FQKLLGIAME 140 LFLLCSDDAE 150 SDVRMVADEC 160 LNKVIKALMD 170 SNLPRLQLEL 180 YKEIKKNGAP 190 RSLRAALWRF 200 AELAHLVRPQ 210 KCRPYLVNLL 220 PCLTRTSKRP 230 EESVQETLAA 240 AVPKIMASFG 250 NFANDNEIKV 260 LLKAFIANLK 270 SSSPTIRRTA 280 AGSAVSICQH 290 SRRTQYFYSW 300 LLNVLLGLLV 310 PVEDEHSTLL 320 ILGVLLTLRY 330 LVPLLQQQVK 340 DTSLKGSFGV 350 TRKEMEVSPS 360 AEQLVQVYEL 370 TLHHTQHQDH 380 NVVTGALELL 390 QQLFRTPPPE 400 LLQTLTAVGG 410 IGQLTAAKEE 420 SGGRSRSGSI 430 VELIAGGGSS 440 CSPVLSRKQK 450 GKVLLGEEEA 460 LEDDSESRSD 470 VSSSALTASV 480 KDEISGELAA 490 SSGVSTPGSA 500 GHDIITEQPR 510 SQHTLQADSV 520 DLASCDLTSS 530 ATDGDEEDIL 540 SHSSSQVSAV 550 PSDPAMDLND 560 GTQASSPISD 570 SSQTTTEGPD 580 SAVTPSDSSE 590 IVLDGTDNQY 600 LGLQIGQPQD 610 EDEEATGILP 620 DEASEAFRNS 630 SMALQQAHLL 640 KNMSHCRQPS 650 DSSVDKFVLR 660 DEATEPGDQE 670 NKPCRIKGDI 680 GQSTDDDSAP 690 LVHCVRLLSA 700 SFLLTGGKNV 710 LVPDRDVRVS 720 VKALALSCVG 730 AAVALHPESF 740 FSKLYKVPLD 750 TTEYPEEQYV 760 SDILNYIDHG 770 DPQVRGATAI 780 LCGTLICSIL 790 SRSRFHVGDW 800 MGTIRTLTGN 810 TFSLADCIPL 820 LRKTLKDESS 830 VTCKLACTAV 840 RNCVMSLCSS 850 SYSELGLQLI 860 IDVLTLRNSS 870 YWLVRTELLE 880 TLAEIDFRLV 890 SFLEAKAENL 900 HRGAHHYTGL 910 LKLQERVLNN 920 VVIHLLGDED 930 PRVRHVAAAS 940 LIRLVPKLFY 950 KCDQGQADPV 960 VAVARDQSSV 970 YLKLLMHETQ 980 PPSHFSVSTI 990 TRIYRGYNLL 1000 PSITDVTMEN 1010 NLSRVIAAVS 1020 HELITSTTRA 1030 LTFGCCEALC 1040 LLSTAFPVCI 1050 WSLGWHCGVP 1060 PLSASDESRK 1070 SCTVGMATMI 1080 LTLLSSAWFP 1090 LDLSAHQDAL 1100 ILAGNLLAAS 1110 APKSLRSSWA 1120 SEEEANPAAT 1130 KQEEVWPALG 1140 DRALVPMVEQ 1150 LFSHLLKVIN 1160 ICAHVLDDVA 1170 PGPAIKAALP 1180 SLTNPPSLSP 1190 IRRKGKEKEP 1200 GEQASVPLSP 1210 KKGSEASAAS 1220 RQSDTSGPVT 1230 TSKSSSLGSF 1240 YHLPSYLKLH 1250 DVLKATHANY 1260 KVTLDLQNST 1270 EKFGGFLRSA 1280 LDVLSQILEL 1290 ATLQDIGKCV 1300 EEILGYLKSC 1310 FSREPMMATV 1320 CVQQLLKTLF 1330 GTNLASQFDG 1340 LSSNPSKSQG 1350 RAQRLGSSSV 1360 RPGLYHYCFM 1370 APYTHFTQAL 1380 ADASLRNMVQ 1390 AEQENDTSGW 1400 FDVLQKVSTQ 1410 LKTNLTSVTK 1420 NRADKNAIHN 1430 HIRLFEPLVI 1440 KALKQYTTTT 1450 CVQLQKQVLD 1460 LLAQLVQLRV 1470 NYCLLDSDQV 1480 FIGFVLKQFE 1490 YIEVGQFRES 1500 EAIIPNIFFF 1510 LVLLSYERYH 1520 SKQIIGIPKI 1530 IQLCDGIMAS 1540 GRKAVTHAIP 1550 ALQPIVHDLF 1560 VLRGTNKADA 1570 GKELETQKEV 1580 VVSMLLRLIQ 1590 YHQVLEMFIL 1600 VLQQCHKENE 1610 DKWKRLSRQI 1620 ADIILPMLAK 1630 QQMHIDSHEA 1640 LGVLNTLFEI 1650 LAPSSLRPVD 1660 MLLRSMFVTP 1670 NTMASVSTVQ 1680 LWISGILAIL 1690 RVLISQSTED 1700 IVLSRIQELS 1710 FSPYLISCTV 1720 INRLRDGDST 1730 STLEEHSEGK 1740 QIKNLPEETF 1750 SRFLLQLVGI 1760 LLEDIVTKQL 1770 KVEMSEQQHT 1780 FYCQELGTLL 1790 MCLIHIFKSG 1800 MFRRITAAAT 1810 RLFRSDGCGG 1820 SFYTLDSLNL 1830 RARSMITTHP 1840 ALVLLWCQIL 1850 LLVNHTDYRW 1860 WAEVQQTPKR 1870 HSLSSTKLLS 1880 PQMSGEEEDS 1890 DLAAKLGMCN 1900 REIVRRGALI 1910 LFCDYVCQNL 1920 HDSEHLTWLI 1930 VNHIQDLISL 1940 SHEPPVQDFI 1950 SAVHRNSAAS 1960 GLFIQAIQSR 1970 CENLSTPTML 1980 KKTLQCLEGI 1990 HLSQSGAVLT 2000 LYVDRLLCTP 2010 FRVLARMVDI 2020 LACRRVEMLL 2030 AANLQSSMAQ 2040 LPMEELNRIQ 2050 EYLQSSGLAQ 2060 RHQRLYSLLD 2070 RFRLSTMQDS 2080 LSPSPPVSSH 2090 PLDGDGHVSL 2100 ETVSPDKDWY 2110 VHLVKSQCWT 2120 RSDSALLEGA 2130 ELVNRIPAED 2140 MNAFMMNSEF 2150 NLSLLAPCLS 2160 LGMSEISGGQ 2170 KSALFEAARE 2180 VTLARVSGTV 2190 QQLPAVHHVF 2200 QPELPAEPAA 2210 YWSKLNDLFG 2220 DAALYQSLPT 2230 LARALAQYLV 2240 VVSKLPSHLH 2250 LPPEKEKDIV 2260 KFVVATLEAL 2270 SWHLIHEQIP 2280 LSLDLQAGLD 2290 CCCLALQLPG 2300 LWSVVSSTEF 2310 VTHACSLIYC 2320 VHFILEAVAV 2330 QPGEQLLSPE 2340 RRTNTPKAIS 2350 EEEEEVDPNT 2360 QNPKYITAAC 2370 EMVAEMVESL 2380 QSVLALGHKR 2390 NSGVPAFLTP 2400 LLRNIIISLA 2410 RLPLVNSYTR 2420 VPPLVWKLGW 2430 SPKPGGDFGT 2440 AFPEIPVEFL 2450 QEKEVFKEFI 2460 YRINTLGWTS 2470 RTQFEETWAT 2480 LLGVLVTQPL 2490 VMEQEESPPE 2500 EDTERTQINV 2510 LAVQAITSLV 2520 LSAMTVPVAG 2530 NPAVSCLEQQ 2540 PRNKPLKALD 2550 TRFGRKLSII 2560 RGIVEQEIQA 2570 MVSKRENIAT 2580 HHLYQAWDPV 2590 PSLSPATTGA 2600 LISHEKLLLQ 2610 INPERELGSM 2620 SYKLGQVSIH 2630 SVWLGNSITP 2640 LREEEWDEEE 2650 EEEADAPAPS 2660 SPPTSPVNSR 2670 KHRAGVDIHS 2680 CSQFLLELYS 2690 RWILPSSSAR 2700 RTPAILISEV 2710 VRSLLVVSDL 2720 FTERNQFELM 2730 YVTLTELRRV 2740 HPSEDEILAQ 2750 YLVPATCKAA 2760 AVLGMDKAVA 2770 EPVSRLLEST 2780 LRSSHLPSRV 2790 GALHGVLYVL 2800 ECDLLDDTAK 2810 QLIPVISDYL 2820 LSNLKGIAHC 2830 VNIHSQQHVL 2840 VMCATAFYLI 2850 ENYPLDVGPE 2860 FSASIIQMCG 2870 VMLSGSEEST 2880 PSIIYHCALR 2890 GLERLLLSEQ 2900 LSRLDAESLV 2910 KLSVDRVNVH 2920 SPHRAMAALG 2930 LMLTCMYTGK 2940 EKVSPGRTSD 2950 PNPAAPDSES 2960 VIVAMERVSV 2970 LFDRIRKGFP 2980 CEARVVARIL 2990 PQFLDDFFPP 3000 QDIMNKVIGE 3010 FLSNQQPYPQ 3020 FMATVVYKVF 3030 QTLHSTGQSS 3040 MVRDWVMLSL 3050 SNFTQRAPVA 3060 MATWSLSCFF 3070 VSASTSPWVA 3080 AILPHVISRM 3090 GKLEQVDVNL 3100 FCLVATDFYR 3110 HQIEEELDRR 3120 AFQSVLEVVA 3130 APGSPYHRLL 3140 TCLRNVHKVT TC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005776 autophagosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016234 inclusion body
Cellular Component GO:0005770 late endosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0099524 postsynaptic cytosol
Cellular Component GO:0099523 presynaptic cytosol
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0048487 beta-tubulin binding
Molecular Function GO:0034452 dynactin binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0031072 heat shock protein binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0002039 p53 binding
Molecular Function GO:0004721 phosphoprotein phosphatase activity
Molecular Function GO:0005522 profilin binding
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007417 central nervous system development
Biological Process GO:0000132 establishment of mitotic spindle orientation
Biological Process GO:0007030 Golgi organization
Biological Process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Biological Process GO:0022008 neurogenesis
Biological Process GO:1905337 positive regulation of aggrephagy
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0050850 positive regulation of calcium-mediated signaling
Biological Process GO:1905291 positive regulation of CAMKK-AMPK signaling cascade
Biological Process GO:0045724 positive regulation of cilium assembly
Biological Process GO:1904504 positive regulation of lipophagy
Biological Process GO:1901526 positive regulation of mitophagy
Biological Process GO:0031648 protein destabilization
Biological Process GO:1905289 regulation of CAMKK-AMPK signaling cascade
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Biological Process GO:0048489 synaptic vesicle transport
Biological Process GO:0047496 vesicle transport along microtubule
Biological Process GO:0042297 vocal learning
Cellular Component GO:0030424 axon
Cellular Component GO:0005814 centriole
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0030659 cytoplasmic vesicle membrane

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.