Overview
| Uniprot ID | P43003 |
|---|
| Protein Name | Excitatory amino acid transporter 1 |
|---|
| Gene Name | SLC1A3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 521 |
IEENEMKKPYQLIAQ |
| 534 |
AQDNETEKPIDSETK |
Function
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515, PubMed:7521911, PubMed:8123008). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity)
Protein Sequence
10
MTKSNGEEPK
20
MGGRMERFQQ
30
GVRKRTLLAK
40
KKVQNITKED
50
VKSYLFRNAF
60
VLLTVTAVIV
70
GTILGFTLRP
80
YRMSYREVKY
90
FSFPGELLMR
100
MLQMLVLPLI
110
ISSLVTGMAA
120
LDSKASGKMG
130
MRAVVYYMTT
140
TIIAVVIGII
150
IVIIIHPGKG
160
TKENMHREGK
170
IVRVTAADAF
180
LDLIRNMFPP
190
NLVEACFKQF
200
KTNYEKRSFK
210
VPIQANETLV
220
GAVINNVSEA
230
METLTRITEE
240
LVPVPGSVNG
250
VNALGLVVFS
260
MCFGFVIGNM
270
KEQGQALREF
280
FDSLNEAIMR
290
LVAVIMWYAP
300
VGILFLIAGK
310
IVEMEDMGVI
320
GGQLAMYTVT
330
VIVGLLIHAV
340
IVLPLLYFLV
350
TRKNPWVFIG
360
GLLQALITAL
370
GTSSSSATLP
380
ITFKCLEENN
390
GVDKRVTRFV
400
LPVGATINMD
410
GTALYEALAA
420
IFIAQVNNFE
430
LNFGQIITIS
440
ITATAASIGA
450
AGIPQAGLVT
460
MVIVLTSVGL
470
PTDDITLIIA
480
VDWFLDRLRT
490
TTNVLGDSLG
500
AGIVEHLSRH
510
ELKNRDVEMG
520
NSVIEENEMK
530
KPYQLIAQDN
540
ETEKPIDSET
KM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009925 |
basal plasma membrane |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0098796 |
membrane protein complex |
| Cellular Component |
GO:0043005 |
neuron projection |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0016595 |
glutamate binding |
| Molecular Function |
GO:0015501 |
glutamate:sodium symporter activity |
| Molecular Function |
GO:0005314 |
high-affinity L-glutamate transmembrane transporter activity |
| Molecular Function |
GO:0005313 |
L-glutamate transmembrane transporter activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0015175 |
neutral L-amino acid transmembrane transporter activity |
| Biological Process |
GO:0006865 |
amino acid transport |
| Biological Process |
GO:0071314 |
cellular response to cocaine |
| Biological Process |
GO:0007268 |
chemical synaptic transmission |
| Biological Process |
GO:1902476 |
chloride transmembrane transport |
| Biological Process |
GO:0070779 |
D-aspartate import across plasma membrane |
| Biological Process |
GO:0140009 |
L-aspartate import across plasma membrane |
| Biological Process |
GO:0051938 |
L-glutamate import |
| Biological Process |
GO:0098712 |
L-glutamate import across plasma membrane |
| Biological Process |
GO:0015813 |
L-glutamate transmembrane transport |
| Biological Process |
GO:0006836 |
neurotransmitter transport |
| Biological Process |
GO:0001504 |
neurotransmitter uptake |
| Biological Process |
GO:0071805 |
potassium ion transmembrane transport |
| Biological Process |
GO:0070633 |
transepithelial transport |
| Biological Process |
GO:0150104 |
transport across blood-brain barrier |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.