Overview
| Uniprot ID | P43004 |
|---|
| Protein Name | Excitatory amino acid transporter 2 |
|---|
| Gene Name | SLC1A2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 304 |
CGKIIAIKDLEVVAR |
| 527 |
QSIYDDMKNHRESNS |
| 559 |
VTLAANGKSADCSVE |
Function
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity)
Protein Sequence
10
MASTEGANNM
20
PKQVEVRMHD
30
SHLGSEEPKH
40
RHLGLRLCDK
50
LGKNLLLTLT
60
VFGVILGAVC
70
GGLLRLASPI
80
HPDVVMLIAF
90
PGDILMRMLK
100
MLILPLIISS
110
LITGLSGLDA
120
KASGRLGTRA
130
MVYYMSTTII
140
AAVLGVILVL
150
AIHPGNPKLK
160
KQLGPGKKND
170
EVSSLDAFLD
180
LIRNLFPENL
190
VQACFQQIQT
200
VTKKVLVAPP
210
PDEEANATSA
220
VVSLLNETVT
230
EVPEETKMVI
240
KKGLEFKDGM
250
NVLGLIGFFI
260
AFGIAMGKMG
270
DQAKLMVDFF
280
NILNEIVMKL
290
VIMIMWYSPL
300
GIACLICGKI
310
IAIKDLEVVA
320
RQLGMYMVTV
330
IIGLIIHGGI
340
FLPLIYFVVT
350
RKNPFSFFAG
360
IFQAWITALG
370
TASSAGTLPV
380
TFRCLEENLG
390
IDKRVTRFVL
400
PVGATINMDG
410
TALYEAVAAI
420
FIAQMNGVVL
430
DGGQIVTVSL
440
TATLASVGAA
450
SIPSAGLVTM
460
LLILTAVGLP
470
TEDISLLVAV
480
DWLLDRMRTS
490
VNVVGDSFGA
500
GIVYHLSKSE
510
LDTIDSQHRV
520
HEDIEMTKTQ
530
SIYDDMKNHR
540
ESNSNQCVYA
550
AHNSVIVDEC
560
KVTLAANGKS
570
ADCSVEEEPW
KREK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097449 |
astrocyte projection |
| Cellular Component |
GO:0030673 |
axolemma |
| Cellular Component |
GO:0044297 |
cell body |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0098796 |
membrane protein complex |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0044306 |
neuron projection terminus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0042734 |
presynaptic membrane |
| Cellular Component |
GO:0031982 |
vesicle |
| Molecular Function |
GO:0033229 |
cysteine transmembrane transporter activity |
| Molecular Function |
GO:0015501 |
glutamate:sodium symporter activity |
| Molecular Function |
GO:0005314 |
high-affinity L-glutamate transmembrane transporter activity |
| Molecular Function |
GO:0005313 |
L-glutamate transmembrane transporter activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0008509 |
monoatomic anion transmembrane transporter activity |
| Molecular Function |
GO:0015175 |
neutral L-amino acid transmembrane transporter activity |
| Biological Process |
GO:0006865 |
amino acid transport |
| Biological Process |
GO:0071314 |
cellular response to cocaine |
| Biological Process |
GO:0007268 |
chemical synaptic transmission |
| Biological Process |
GO:0070779 |
D-aspartate import across plasma membrane |
| Biological Process |
GO:0006750 |
glutathione biosynthetic process |
| Biological Process |
GO:0140009 |
L-aspartate import across plasma membrane |
| Biological Process |
GO:0070778 |
L-aspartate transmembrane transport |
| Biological Process |
GO:0098712 |
L-glutamate import across plasma membrane |
| Biological Process |
GO:0015813 |
L-glutamate transmembrane transport |
| Biological Process |
GO:0098810 |
neurotransmitter reuptake |
| Biological Process |
GO:0006836 |
neurotransmitter transport |
| Biological Process |
GO:0070207 |
protein homotrimerization |
| Biological Process |
GO:0070633 |
transepithelial transport |
| Biological Process |
GO:0150104 |
transport across blood-brain barrier |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.