Search Results
Overview
| Uniprot ID | P43034 |
|---|---|
| Protein Name | Platelet-activating factor acetylhydrolase IB subunit beta |
| Gene Name | PAFAH1B1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 46 | VNEELDKKYAGLLEK |
| 53 | KYAGLLEKKWTSVIR |
| 54 | YAGLLEKKWTSVIRL |
| 88 | SGGPLGQKRDPKEWI |
Function
Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0008247 | 1-alkyl-2-acetylglycerophosphocholine esterase complex |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0090176 | microtubule cytoskeleton organization involved in establishment of planar polarity |
| Biological Process | GO:0031023 | microtubule organizing center organization |
| Biological Process | GO:0051012 | microtubule sliding |
| Biological Process | GO:0007017 | microtubule-based process |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0007405 | neuroblast proliferation |
| Biological Process | GO:0050885 | neuromuscular process controlling balance |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:0007097 | nuclear migration |
| Biological Process | GO:0062234 | platelet activating factor catabolic process |
| Biological Process | GO:0046469 | platelet activating factor metabolic process |
| Biological Process | GO:0045773 | positive regulation of axon extension |
| Biological Process | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| Biological Process | GO:0040019 | positive regulation of embryonic development |
| Biological Process | GO:0045931 | positive regulation of mitotic cell cycle |
| Biological Process | GO:0038026 | reelin-mediated signaling pathway |
| Biological Process | GO:0070507 | regulation of microtubule cytoskeleton organization |
| Biological Process | GO:0008090 | retrograde axonal transport |
| Biological Process | GO:0017145 | stem cell division |
| Biological Process | GO:0019226 | transmission of nerve impulse |
| Biological Process | GO:0047496 | vesicle transport along microtubule |
| Cellular Component | GO:0000235 | astral microtubule |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0090724 | central region of growth cone |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005881 | cytoplasmic microtubule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005871 | kinesin complex |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005875 | microtubule associated complex |
| Cellular Component | GO:0031514 | motile cilium |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0032420 | stereocilium |
| Molecular Function | GO:0034452 | dynactin binding |
| Molecular Function | GO:0070840 | dynein complex binding |
| Molecular Function | GO:0045505 | dynein intermediate chain binding |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0051010 | microtubule plus-end binding |
| Molecular Function | GO:0043274 | phospholipase binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Biological Process | GO:0001675 | acrosome assembly |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0008344 | adult locomotory behavior |
| Biological Process | GO:0060117 | auditory receptor cell development |
| Biological Process | GO:0048854 | brain morphogenesis |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0021895 | cerebral cortex neuron differentiation |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0090102 | cochlea development |
| Biological Process | GO:0021540 | corpus callosum morphogenesis |
| Biological Process | GO:0043622 | cortical microtubule organization |
| Biological Process | GO:0051660 | establishment of centrosome localization |
| Biological Process | GO:0000132 | establishment of mitotic spindle orientation |
| Biological Process | GO:0042249 | establishment of planar polarity of embryonic epithelium |
| Biological Process | GO:0007281 | germ cell development |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0021819 | layer formation in cerebral cortex |
| Biological Process | GO:0007611 | learning or memory |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.