Search Results
Overview
| Uniprot ID | P43121 |
|---|---|
| Protein Name | Cell surface glycoprotein MUC18 |
| Gene Name | MCAM |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 153 | LGIPVNSKEPEEVAT |
Function
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration
Protein Sequence
10
MGLPRLVCAF
20
LLAACCCCPR
30
VAGVPGEAEQ
40
PAPELVEVEV
50
GSTALLKCGL
60
SQSQGNLSHV
70
DWFSVHKEKR
80
TLIFRVRQGQ
90
GQSEPGEYEQ
100
RLSLQDRGAT
110
LALTQVTPQD
120
ERIFLCQGKR
130
PRSQEYRIQL
140
RVYKAPEEPN
150
IQVNPLGIPV
160
NSKEPEEVAT
170
CVGRNGYPIP
180
QVIWYKNGRP
190
LKEEKNRVHI
200
QSSQTVESSG
210
LYTLQSILKA
220
QLVKEDKDAQ
230
FYCELNYRLP
240
SGNHMKESRE
250
VTVPVFYPTE
260
KVWLEVEPVG
270
MLKEGDRVEI
280
RCLADGNPPP
290
HFSISKQNPS
300
TREAEEETTN
310
DNGVLVLEPA
320
RKEHSGRYEC
330
QGLDLDTMIS
340
LLSEPQELLV
350
NYVSDVRVSP
360
AAPERQEGSS
370
LTLTCEAESS
380
QDLEFQWLRE
390
ETGQVLERGP
400
VLQLHDLKRE
410
AGGGYRCVAS
420
VPSIPGLNRT
430
QLVNVAIFGP
440
PWMAFKERKV
450
WVKENMVLNL
460
SCEASGHPRP
470
TISWNVNGTA
480
SEQDQDPQRV
490
LSTLNVLVTP
500
ELLETGVECT
510
ASNDLGKNTS
520
ILFLELVNLT
530
TLTPDSNTTT
540
GLSTSTASPH
550
TRANSTSTER
560
KLPEPESRGV
570
VIVAVIVCIL
580
VLAVLGAVLY
590
FLYKKGKLPC
600
RRSGKQEITL
610
PPSRKSELVV
620
EVKSDKLPEE
630
MGLLQGSSGD
640
KRAPGDQGEK
YIDLRH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005886 | plasma membrane |
| Biological Process | GO:0009653 | anatomical structure morphogenesis |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0003094 | glomerular filtration |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0061042 | vascular wound healing |
Reference
PMID: N/A