Search Results

Overview

Uniprot IDP43244
Protein NameMatrin-3
Gene NameMatr3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
3 *****MSKSFQQSSL
473 VRVHLSQKYKRIKKP
524 AEPYGKIKNYILMRM
617 SKTDGAQKTENPAEG

Function

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins

Protein Sequence

10 MSKSFQQSSL 20 GRDSQGHGRD 30 LSAAGIGLLA 40 AATQSLSMPA 50 SLGRMNQGTA 60 RLASLMNLGM 70 SSSLNQQGAH 80 SALSSASTSS 90 HNLQSIFNIG 100 SRGPLPLSSQ 110 HRGDTDQASN 120 ILASFGLSAR 130 DLDELSRYPE 140 DKITPENLPQ 150 ILLQLKRRRT 160 EEGPTLSYGR 170 DGRSATREPP 180 YRVPRDDWEE 190 KRHFRRDSFD 200 DRGPSLNPVL 210 DYDHGSRSQE 220 SGYYDRMDYE 230 DDRLRDGERC 240 RDDSFFGETS 250 HNYHKFDSEY 260 ERMGRGPGPL 270 QERSLFEKKR 280 GAPPSSNIED 290 FHGLLPKGYP 300 HLCSICDLPV 310 HSNKEWSQHI 320 NGASHSRRCQ 330 LLLEIYPEWN 340 PDNDTGHTMG 350 DPFMLQQSTN 360 PAPGILGPPP 370 PSFHLGGPAV 380 GPRGNLGAGN 390 GNLQGPRHMQ 400 KGRVETSRVV 410 HIMDFQRGKN 420 LRYQLLQLVE 430 PFGVISNHLI 440 LNKINEAFIE 450 MATTEDAQAA 460 VDYYTTTPAL 470 VFGKPVRVHL 480 SQKYKRIKKP 490 EGKPDEKFDQ 500 KQELGRVIHL 510 SNLPHSGYSD 520 SAVLKLAEPY 530 GKIKNYILMR 540 MKSQAFIEME 550 TREDAMAMVD 560 HCLKKALWFQ 570 GRCVKVDLSE 580 KYKKLVLRIP 590 NRGIDLLKKD 600 KSRKRSYSPD 610 GKESPSDKKS 620 KTDGAQKTEN 630 PAEGKEQEEK 640 SGEDGEKDTK 650 DDQTEQEPSM 660 LLESEDELLV 670 DEEEAAALIE 680 SGSSVGDETD 690 LANLGDVSSD 700 GKKEPSDKAV 710 KKDASATSKK 720 KLKKVDKIEE 730 LDQENEAALE 740 NGIKNEENTE 750 PGAESAENAD 760 DPNKDASDNS 770 DGQNDENKED 780 YTIPDEYRIG 790 PYQPNVPGGI 800 DYVIPKTGFY 810 CKLCSLFYTN 820 EEVAKNTHCS 830 SLPHYQKLKK 840 FLNKLAEERR QKKES

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0035198 miRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0002218 activation of innate immune response
Biological Process GO:0001825 blastocyst formation
Biological Process GO:0003170 heart valve development
Biological Process GO:0045087 innate immune response
Biological Process GO:0010608 post-transcriptional regulation of gene expression
Biological Process GO:0003281 ventricular septum development

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.