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Overview

Uniprot ID	P43277
Protein Name	Histone H1.3
Gene Name	H1-3
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
35	GAAAGKRKASGPPVS
65	VSLAALKKALAAAGY

Function

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:12808097). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:12808097). Together with histone H1-3, histone H1-3 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-3 has a high affinity for introns and regulates splicing by affecting RNA polymerase II (RNAPII) elongation (By similarity). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (PubMed:12808097)

Protein Sequence

10 MSETAPAAPA 20 APAPVEKTPV 30 KKKAKKTGAA 40 AGKRKASGPP 50 VSELITKAVA 60 ASKERSGVSL 70 AALKKALAAA 80 GYDVEKNNSR 90 IKLGLKSLVS 100 KGTLVQTKGT 110 GASGSFKLNK 120 KAASGEAKPK 130 AKKAGAAKAK 140 KPAGAAKKPK 150 KATGAATPKK 160 TAKKTPKKAK 170 KPAAAAGAKK 180 VSKSPKKVKA 190 AKPKKAAKSP 200 AKAKAPKAKA 210 SKPKASKPKA 220 TKAKKAAPRK K

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000791	euchromatin
Cellular Component	GO:0000792	heterochromatin
Cellular Component	GO:0000786	nucleosome
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003690	double-stranded DNA binding
Molecular Function	GO:0031492	nucleosomal DNA binding
Molecular Function	GO:0030527	structural constituent of chromatin
Biological Process	GO:0030261	chromosome condensation
Biological Process	GO:0045910	negative regulation of DNA recombination
Biological Process	GO:0006334	nucleosome assembly
Biological Process	GO:0048024	regulation of mRNA splicing, via spliceosome

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.