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Overview

Uniprot IDP43278
Protein NameHistone H1.0
Gene NameH1-0
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
164 AKKPKIVKVKPVKAS
55 QSIQKYIKSHYKVGE
82 LVTTGVLKQTKGVGA

Function

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division

Protein Sequence

10 MTENSTSTPA 20 AKPKRAKAAK 30 KSTDHPKYSD 40 MIVAAIQAEK 50 NRAGSSRQSI 60 QKYIKSHYKV 70 GENADSQIKL 80 SIKRLVTTGV 90 LKQTKGVGAS 100 GSFRLAKGDE 110 PKRSVAFKKT 120 KKEVKKVATP 130 KKAAKPKKAA 140 SKAPSKKPKA 150 TPVKKAKKKP 160 AATPKKAKKP 170 KIVKVKPVKA 180 SKPKKAKPVK 190 PKAKSSAKRA SKKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0000786 nucleosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0003680 minor groove of adenine-thymine-rich DNA binding
Molecular Function GO:0031492 nucleosomal DNA binding
Molecular Function GO:0031491 nucleosome binding
Molecular Function GO:0030527 structural constituent of chromatin
Biological Process GO:0030261 chromosome condensation
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0045910 negative regulation of DNA recombination
Biological Process GO:0006334 nucleosome assembly

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.