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Overview

Uniprot IDP43308
Protein NameTranslocon-associated protein subunit beta
Gene NameSSR2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
27 GARLLASKSLLNRYA

Function

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins

Protein Sequence

10 MRLLSFVVLA 20 LFAVTQAEEG 30 ARLLASKSLL 40 NRYAVEGRDL 50 TLQYNIYNVG 60 SSAALDVELS 70 DDSFPPEDFG 80 IVSGMLNVKW 90 DRIAPASNVS 100 HTVVLRPLKA 110 GYFNFTSATI 120 TYLAQEDGPV 130 VIGSTSAPGQ 140 GGILAQREFD 150 RRFSPHFLDW 160 AAFGVMTLPS 170 IGIPLLLWYS 180 SKRKYDTPKT KKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Biological Process GO:0006613 cotranslational protein targeting to membrane
Biological Process GO:0031204 post-translational protein targeting to membrane, translocation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.